Focus Areas

Bioinstrumentation and Devices

Jennifer Barton – miniature endoscopes
Ali Bilgin – MRI and X-ray optimization
Stephen Cowen – devices monitoring animal learning and movement
Jean-Marc Fellous – neural implants
Wolfgang Fink – artificial vision and vision prostheses
Dongkyun Kang – miniature microscopy devices
David Margolis – in vivo bone strain measurement
Ingmar Riedel-Kruse – devices integrating microfluidics, microscopy and optogenetic stimulation
Marek Romanowski – contrast agent development
Travis Sawyer - development of optical imaging endoscopes for cancer detection
Marvin Slepian – artificial heart
Shang Song – implantable biohybrid devices for tissue and organ replacement
T. Judith Su – microfabrication of optical instrument
John Szivek – implantable sensors and radio telemetry
Urs Utzinger – fiber optic sensing and microscopy
Jason Wertheim – 3D printing and bioreactor development for tissue engineering
Russell Witte – ultrasound and electrode technology development
Jeong-Yeol Yoon – handheld LAMP and PCR systems for pathogen identification

Biomaterials and Tissue Engineering

Kellen Chen – three dimensional tissue engineered scar to mimic physiologic human healing
Jared Churko – generation and assembly of various iPSC-derived cell types into tissue constructs
Geoffrey Gurtner – use of 3D tissue engineered scaffolds that mimic scar formation in vitro
Philipp Gutruf – soft inorganic electronic materials and sensors
Kavan Hazeli – design, manufacturing, testing, and optimizing biomaterials and medical implants
Minkyu Kim – artificial protein polymer design, protein and polymer synthesis, (bio)polymer physics and chemistry, synthetic biology, bioconjugation, soft materials, and antimicrobial biomaterials
David Margolis – bone and cartilage tissue engineering
Ingmar Riedel-Kruse – synthetic multicellular systems with applications for health, environment, biosynthesis and biomaterials
Marek Romanowski – nanoparticle and liposome materials for drug delivery
Marvin Slepian – polymeric biomaterials, biodegradable stents, drug-eluting stents and artificial heart
Shang Song – cell-based microfluidics for organ-on-chip systems; engineered cellular microenvironment for neural regeneration, muscle rehabilitation, diabetes, and bone tissue engineering; cell-material constructs to mimic tissue interfaces
John Szivek – 3D-printable materials for implantation with adult stem cells
Jason Wertheim – liver, kidney and vascular tissue engineering
Jeong-Yeol Yoon – paper-based systems for tissue engineering and organ-on-a-chip applications
Yitshak Zohar – microfluidic systems for bio-chemical-medical applications

Biomechanics

Kellen Chen – mechanical signaling on fibrosis and regeneration across various organ systems including the skin
Wolfgang Fink – ocular biomechanics
Geoffrey Gurtner – targeting mechanotransduction pathways to prevent fibrosis or mitigate the foreign body response (FBR) to biomedical implants
Samantha Harris – force measurements in cardiac muscle cells to understand mechanisms of cardiac contraction
Kavan Hazeli – human centered design and injury prevention
Minkyu Kim – molecular biomechanics
Daniel Latt – foot and ankle biomechanics
Zong-Ming Li – musculoskeletal biomechanics
David Margolis – musculoskeletal tissue biomechanics
Kristen Renner – various techniques including motion capture to optimize the outcomes of orthopedic surgeries and sports injuries
Ingmar Riedel-Kruse – synthetic cell-cell adhesins to shape the visco-elastic properties of novel biomaterials
Marvin Slepian – cardiovascular and tubular organ functionality
Shang Song – cellular biomechanics; regenerative rehabilitation
John Szivek – load sharing induced by orthopedic implants
Jil C. Tardiff – mechanical properties of cardiac function in health and disease assessed at the cellular and whole heart levels
Russell Witte – ultrasound elasticity and shear wave imaging

Biomedical Imaging and Spectroscopy

Jennifer Barton – optical coherence tomography and fluorescence spectroscopy
Ali Bilgin – accelerated MRI and MR parameter mapping, cancer imaging
Nan-kuei Chen – motion-immune clinical MRI, MRI corrections and improvements
Wolfgang Fink – Scheimpflug imaging and ray tracing
Julia Fisher – development of statistical methods for functional MRI data, simulation of functional neuroimaging (MRI) data
Arthur Gmitro – multimodality imaging methods and techniques, confocal microendoscopy
Elizabeth Hutchinson – quantitative preclinical MRI
Dongkyun Kang – in vivo microscopy
Jen Watson Koevary – cardiovascular imaging
Zong-Ming Li – MRI, CT, and ultrasound imaging
Manoj Saranathan – ultrafast and dynamic MRI, MRI physics and reconstruction with applications to cancer, metabolism, and inflammation
Travis Sawyer - development of new imaging techniques and algorithms for disease diagnosis and screening
T. Judith Su – optical resonators and biophotonics
Jil C. Tardiff – time-resolved and steady-state FRET, differential scanning calorimetry, isothermal calorimetry, stopped-flow fluorescence spectroscopy, regulated in vitro motility, intramyocellular calcium flux
Ted Trouard – neurological imaging via MRI
Evan Unger – ultrasound agents
Urs Utzinger – clinical imaging instrumentation to evaluate gynecological and gastrointestinal cancer
Srinivasan Vedantham – design, development and clinical translation of novel X-ray/CT imaging systems and techniques
Russell Witte – hybrid imaging with light, sound and microwaves
Jeong-Yeol Yoon – smartphone app instant optical scanner

Biomedical Informatics

Ali Bilgin – data compression
Kellen Chen – single cell RNA sequencing of human disease tissue and animal model response to therapeutics
Jared Churko – single-cell RNA sequencing, ChIP sequencing, whole genome sequencing
Jean-Marc Fellous – computational neuroscience, biophysical modeling
Wolfgang Fink – computer-based classification of visual field data
Julia Fisher – experimental design, statistical analysis of experimental and observational data, biomedical informatics
Geoffrey Gurtner – gene analysis with single cell RNA sequencing from various cell types from a variety of disease states
Vignesh Subbian – computational medicine, biomedical data science and informatics

Biosensors

Stephen Cowen – devices sensing neural activity and dopamine in behaving animals
Geoffrey Gurtner – wearable electronics to sense the current wound state and deliver therapeutic electrical stimulation to improve healing
Philipp Gutruf – soft, bio-integrated, wireless battery-free sensor systems
Samantha Harris – developing force and proximity sensors using FRET.
David Margolis – in vivo bone strain and force measurements
Marvin Slepian – gene sequencing and platelet activation
T. Judith Su – label-free single-molecule detection
John Szivek – implantable strain and load measurement systems
Urs Utzinger – biosensors for minimally invasive cancer detection
Jeong-Yeol Yoon – smartphone biosensors for medical diagnostics

Cardiovascular Biomedical Engineering

Jennifer Barton – minimally invasive procedures for the treatment of cardiovascular disease
Jared Churko – optical mapping, contraction force, cardiac cell generation from iPSCs
Wolfgang Fink – wearable-sensor-based stress management
Samantha Harris – cardiovascular diseases such as cardiomyopathies and how engineering approaches can provide insights into cardiac physiology
Minkyu Kim – atherosclerosis
Jen Watson Koevary – therapeutics and toxicity screening
Marek Romanowski – augmented and holographic imaging for surgical guidance
Marvin Slepian – end-stage congestive heart failure and artificial replacements to bridge support until transplant
T. Judith Su – micropatterning of extracellular matrix molecules for cellular control
Jil C. Tardiff – mouse models of genetic cardiomyopathies and the development of small molecule inhibitors to alter disease progression
Evan Unger – nanodroplets for sonothrombolysis treatment of acute myocardial infarction
Jason Wertheim – endothelial biology and blood vessel development and engineering
Russell Witte – acoustoelectric imaging
Jeong-Yeol Yoon – adhesion between tissue and implanted cardiovascular implanted devices

Nanomedicine

Minkyu Kim – nanoscale biopolymer physics
Marek Romanowski – new methods of delivery of therapeutic and diagnostic agents
Marvin Slepian – local drug delivery and novel therapeutics
T. Judith Su – microfluidics
Evan Unger – nanoemulsion for oxygen delivery for clinical trials for stroke and brain cancer
Jason Wertheim – nanoparticle development and drug delivery
Yitshak Zohar – organ on a chip

Neuroengineering

Nan-kuei Chen – human brain connectivity imaging
Jared Churko – generation of neural progenitor cells, neurons and other brain-specific cells from iPSCs
Stephen Cowen – devices sensing neural activity and dopamine in behaving animals
Erika Eggers – visual neuroscience, studying the function of retinal neurons with single-cell electrophysiology, confocal imaging, optogenetics and modeling
Jean-Marc Fellous – in vivo behaving neurophysiology, spatial navigation, memory and emotions circuits
Wolfgang Fink – human and brain-machine interfaces
Philipp Gutruf – all optical, wireless and subdermally implanted optogenetic tools
Zong-Ming Li – hand motor control
Marek Romanowski – augmented and holographic imaging for surgical guidance
Manoj Saranathan – MRI of deep brain structures, MRI-guided deep brain stimulation surgery, neuro-image processing
Shang Song – conductive biomaterials and neural stem cells for neurological diseases; organ-on-chip for neural applications; generation of neural progenitor cells
Vignesh Subbian – traumatic brain injury and intelligent systems and applied machine learning for neurological disorders
Ted Trouard – development and application of MRI for neuroimaging and drug delivery in neurological disorders
Urs Utzinger – whole-brain imaging microscopy
Russell Witte – electrical brain imaging