Dongkyun Kang
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Associate Professor of Optical Sciences
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Associate Professor of Biomedical Engineering
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Associate Professor, BIO5 Institute
Degrees
- Ph.D. Mechanical Engineering
- Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, Republic of
- Design, analysis and application of confocal self-interference microscopy
- M.S. Mechanical Engineering
- Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, Republic of
- B.S. Mechanical Engineering
- Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, Republic of
Work Experience
- Harvard Medical School and Massachusetts General Hospital (2016 - 2017)
- Harvard Medical School and Massachusetts General Hospital (2009 - 2016)
- Harvard Medical School and Massachusetts General Hospital (2007 - 2009)
- Korea Advanced Institute of Science and Technology (2006 - 2007)
Interests
Teaching
Biomedical Optics; Biomedical instrumentation; Medical device development
Research
My research is focused on developing novel optical microscopy technologies and improving patient care using these technologies. My research area includes (1) lowcost smartphone in vivo microscopy, (2) high-speed comprehensive in vivo endomicroscopy, and (3) ultraminiature endomicroscopy.Low-cost smartphone in vivo microscopy: I am currently leading a NIH-sponsored research project for developing smartphone confocal microscope and diagnosing Kaposi's sarcoma in Uganda with the smartphone confocal microscope. I will further advance the smartphone microscopy technology and address other applications, including diagnosis of cervical and oral cancers in low-resource settings, large-population screening of skin cancers in the US, and aiding science and medical educations.High-speed comprehensive in vivo endomicroscopy: I have previously developed a high-speed confocal microscopy system and endoscopic imaging catheters and acquired largest in vivo confocal images of human organ reported. At the UA, I plan to further advance the technology by i) increasing the imaging speed by orders of magnitude and ii) incorporating fluorescence imaging modality.Ultraminiature endomicroscopy: In my previous research, I have developed miniature endoscopic catheters that can visualize internal organs in vivo through a needle-sized device. At the UA, I will develop microscopic imaging catheter with a extremely small diameter and utilize it for guiding cancer diagnosis and treatment.
Courses
Biomedical Instrumentation
BME 330 (Spring 2020)
BME 330 (Spring 2019)
Meas&Data Anls Bio Eng
BME 417 (Fall 2023)
BME 417 (Fall 2022)
BME 417 (Fall 2021)
BME 517 (Fall 2023)
BME 517 (Fall 2022)
BME 517 (Fall 2021)
BME 517 (Spring 2021)
ECE 517 (Spring 2021)
Rsrch Meth Biomed Engr
BME 592 (Spring 2023)
BME 592 (Fall 2022)
BME 592 (Fall 2021)
BME 592 (Spring 2021)
Independent Study
OPTI 599 (Fall 2023)
OPTI 599 (Summer I 2023)
OPTI 599 (Fall 2018)
Biomed Optics+Biphotonic
BME 630 (Spring 2023)
BME 630 (Spring 2022)
BME 630 (Fall 2020)
BME 630 (Fall 2018)
OPTI 630 (Spring 2023)
OPTI 630 (Spring 2022)
OPTI 630 (Fall 2020)
OPTI 630 (Fall 2019)
OPTI 630 (Fall 2018)
Biomedical Engr Seminar
BME 696A (Fall 2020)
BME 696A (Fall 2019)
Bme Student Forum
BME 696C (Spring 2021)
BME 696C (Spring 2020)
Directed Graduate Research
OPTI 792 (Spring 2022)
OPTI 792 (Fall 2021)
OPTI 792 (Fall 2020)
Research
OPTI 900 (Spring 2020)
Master's Report
OPTI 909 (Spring 2020)
Thesis
BME 910 (Fall 2023)
BME 910 (Spring 2023)
BME 910 (Fall 2022)
OPTI 910 (Spring 2021)
OPTI 910 (Fall 2020)
OPTI 910 (Spring 2020)
OPTI 910 (Fall 2019)
OPTI 910 (Spring 2019)
Dissertation
BME 920 (Fall 2023)
OPTI 920 (Fall 2023)
OPTI 920 (Spring 2023)
OPTI 920 (Fall 2022)
OPTI 920 (Spring 2022)
OPTI 920 (Fall 2021)
OPTI 920 (Spring 2021)
OPTI 920 (Fall 2020)
OPTI 920 (Spring 2020)
OPTI 920 (Fall 2019)
OPTI 920 (Spring 2019)
Selected Publications
Chapters
- Zhu, W., Gong, C., Kulkarni, N., Nguyen, C., & Kang, D. (2019). Smartphone based microscopes. In Smartphone based medical diagnostics.
- Do, D., Tearney, G. J., & Kang, D. (2017). Miniature confocal microscopy devices for imaging skin. In Reflectance confocal microscopy of cutaneous tumors.
- Woods, K., Kang, D., Neumann, H., Vieth, M., & Coron, E. (2014). Confocal Endomicroscopy. In Pathobiology of Human Disease.
Journals/Publications
- Zhao, J., Kulkarni, N., Dobo, E., Khan, M. J., Yang, E., & Kang, D. (2022). Investigation of different wavelengths for scattering-based light sheet microscopy. Biomedical optics express, 13(7), 3882-3892.
- Curiel-Lewandrowski, C., Stratton, D. B., Gong, C., & Kang, D. (2021). Preliminary imaging of skin lesions with near-infrared, portable, confocal microscopy. Journal of the American Academy of Dermatology, 85(6), 1624-1625.
- Kang, D., Gmitro, A., Choi, H., Nishant, A., Kulkarni, N., Masciola, A., Kim, K., Freeman, E. E., Semeere, A., & Nakalembe, M. (2021). Low-cost, chromatic confocal endomicroscope for cellular imaging in vivo. Biomedical Optics Express, 12(9), 5629. doi:10.1364/boe.434892
- Kulkarni, N., Masciola, A., Nishant, A., Kim, K. J., Choi, H., Gmitro, A., Freeman, E. E., Semeere, A., Nakalembe, M., & Kang, D. (2021). Low-cost, chromatic confocal endomicroscope for cellular imaging. Biomedical optics express, 12(9), 5629-5643.
- McMahon, D. E., Oyesiku, L., Semeere, A., Kang, D., & Freeman, E. E. (2021). Novel Diagnostics for Kaposi Sarcoma and Other Skin Diseases in Resource-Limited Settings. Dermatologic clinics, 39(1), 83-90.
- Ozcan, A., Kang, D., & Tearney, G. J. (2021). Introduction to Special Biomedical Optical Imaging Issue. Lasers in Surgery and Medicine, 53(6), 747-747. doi:10.1002/lsm.23413
- Seth, D., Kang, D., Tearney, G. J., Seth, D., Semeere, A., Rajadhyaksha, M., Oyesiku, L., Osman, H., Namaganda, P., Mcmahon, D. E., Martin, J. N., Lukande, R., Laker-oketta, M., Kang, D., Gonzalez, S., Freeman, E. E., & Anderson, R. R. (2021). Feasibility and implementation of portable confocal microscopy for point-of-care diagnosis of cutaneous lesions in a low-resource setting.. Journal of the American Academy of Dermatology, 84(2), 499-502. doi:10.1016/j.jaad.2020.04.147
- Yang, E., O'neal, P. K., Nguyen, C. D., Kulkarni, N., & Kang, D. (2021). Scattering-Based Light-Sheet Microscopy for Rapid Cellular Imaging of Fresh Tissue.. Lasers in surgery and medicine, 53(6), 872-879. doi:10.1002/lsm.23361
- Yelin, D., Tshikudi, D. M., Simandoux, O., Nadkarni, S. K., Kang, D., Cott, E. M., & Andrawes, M. N. (2021). Imaging the dynamics and microstructure of fibrin clot polymerization in cardiac surgical patients using spectrally encoded confocal microscopy.. American journal of hematology, 96(8), 968-978. doi:10.1002/ajh.26217
- Zhao, J., Kose, K., Kang, D., Jain, M., Harris, U. G., & Curiel-lewandrowski, C. (2021). Deep Learning-Based Denoising in High-Speed Portable Reflectance Confocal Microscopy.. Lasers in surgery and medicine, 53(6), 880-891. doi:10.1002/lsm.23410
- Gong, C., Stratton, D. B., Curiel-Lewandrowski, C. N., & Kang, D. (2020). Speckle-free, near-infrared portable confocal microscope. Applied optics, 59(22), G41-G46.
- Nguyen, C. D., O'Neal, P. K., Kulkarni, N., Yang, E., & Kang, D. (2020). Scattering-Based Light-Sheet Microscopy for Rapid Cellular Imaging of Fresh Tissue. Lasers in surgery and medicine.
- Zhu, W., Pirovano, G., O'Neal, P. K., Gong, C., Kulkarni, N., Nguyen, C. D., Brand, C., Reiner, T., & Kang, D. (2020). Smartphone epifluorescence microscopy for cellular imaging of fresh tissue in low-resource settings. Biomedical optics express, 11(1), 89-98.
- Gong, C., Kulkarni, N., Zhu, W., Nguyen, C. D., Curiel-Lewandrowski, C., & Kang, D. (2019). Low-cost, high-speed near infrared reflectance confocal microscope. Biomedical optics express, 10(7), 3497-3505.
- Kang, D., Do, D., Ryu, J., Grant, C. N., Giddings, S. L., Rosenberg, M., Hesterberg, P. E., Yuan, Q., Garber, J. J., Katz, A. J., & Tearney, G. J. (2019). A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule. Lasers in surgery and medicine.
Proceedings Publications
- Zhao, J., Kose, K., Kang, D., Jain, M., Harris, U., & Curiel-lewandrowski, C. (2021). Deep learning-based denoising in spectrally-encoded confocal microscopy. In Endoscopic Microscopy XVI, 11620.
- Kang, D., Gong, C., & Chidambaram, J. D. (2020). Cellular imaging of the cornea with a low-cost, portable confocal microscope. In Biophotonics Congress: Biomedical Optics 2020 (Translational, Microscopy, OCT, OTS, BRAIN).
- Gong, C., Gong, C., Kulkarni, N., Kulkarni, N., Zhu, W., Zhu, W., Nguyen, C. D., Nguyen, C. D., Curiel-lewandrowski, C., Curiel-lewandrowski, C., Kang, D., & Kang, D. (2019). High-Speed Blood Flow Imaging with Scanless Confocal Microscope. In 2019 IEEE Photonics Conference (IPC).
- Gong, C., Kulkarni, N., Zhu, W., Nguyen, C. D., Curiel-lewandrowski, C., & Kang, D. (2019). Low-cost, high-speed near-infrared confocal microscope. In Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP).
- Nguyen, C. D., Gong, C., Kulkarni, N., Zhu, W., Curiel-lewandrowski, C., & Kang, D. (2019). Light sheet microscopy of human skin in vivo. In Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP).
- Tshikudi, D. M., Simandoux, O., Kang, D., Yelin, D., Nadkarni, S. K., Cott, E. M., & Andrawes, M. N. (2019). Evaluating fibrin polymerization dynamics in three dimensions peri-operatively in cardiac surgical patients using spectrally encoded confocal microscopy (SECM) (Conference Presentation). In Diagnostic and Therapeutic Applications of Light in Cardiology 2019, 10855.
- Zhu, W., Pirovano, G., Gong, C., Kulkarni, N., Nguyen, C. D., Brand, C., Reiner, T., & Kang, D. (2019). Smartphone-based epifluorescence microscope for fresh tissue imaging. In Novel Biophotonics Techniques and Applications V.
- Kang, D. (2018). Spectrally encoded confocal microscopy for comprehensive and low-cost in vivo cellular imaging. In Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS).
- Kang, D. (2017). In vivo cellular imaging with spectrally encoded confocal microscopy. In Conference on Lasers and Electro-Optics.
- Unglert, C., Namati, E., Yoo, H., Liu, L., Kang, D., Tearney, G. J., & Bouma, B. E. (2010). High Resolution Reflectance Microscopy Techniques For 3-Dimensional Imaging Of The Alveolar Structure. In D99. THE FUTURE IS NOW: ADVANCED IMAGING OF LUNG STRUCTURE AND FUNCTION.
- Kang, D., Suter, M. J., Boudoux, C., Yachimski, P. S., Bouma, B. E., Nishioka, N. S., & Tearney, G. J. (2009). Combined spectrally encoded confocal microscopy and optical frequency domain imaging system. In Endoscopic Microscopy IV, 7172.
- Kim, J., Kang, D., Cho, H., Sohn, Y. S., & Gweon, D. (2005). Design of real-time confocal microscopy using spectral encoding technique and slit aperture. In Optomechatronic Sensors and Instrumentation, 6049.
- Kang, D. K., Seo, J., & Gweon, D. G. (2002). Reflecting optical system to increase signal intensity in confocal microscopy. In Optical Design and Testing, 4927, 396-403.
- Lee, J. H., Yoon, H. K., Kang, D. K., Lee, S. T., & Gweon, D. G. (2002). New focusing lens system and tolerance analysis for near field recording system. In Advanced Optical Storage Technology, 4930, 359-366.
- Kang, D. K., Seo, J. W., Park, S. L., & Gweon, D. G. (2001). 3D image reconstruction using optical sectioning in confocal scanning microscopy. In Optomechatronic Systems II, 4564, 58-65.
Poster Presentations
- Kang, D. (2019, November). Low-cost confocal microscopy for point-of-care cellular morphologic imaging in vivo. NIH-IEEE Health Innovations Point-of-care Technology.
- Freeman, E. E., Semeere, A., Namaganda, P., Laker-Oketta, M., Lukande, R., Tearney, G. J., Gonzalez, S., Rajadhyaksha, M., Anderson, R. R., Martin, J., & Kang, D. (2017, July). Portable Confocal Microscopy as a Diagnostic Tool for Kaposi’s Sarcoma in Africa. International Conference on Malignancies in HIV/AIDS (ICMH).
Presentations
- Kang, D. (2020, April). Cellular Imaging of the Cornea with a Low-Cost, Portable Confo- cal Microscope. OSA Biophotonics Congress. Virtual: OSA.
- Kang, D. (2020, February). Speckle-free, spectrally-encoded confocal microscopy. Photonics West. San Francisco: SPIE.
- Kang, D. (2020, September). Miniature, hyperchromatic objective lens for chromatic confocal endomicroscope. IEEE Photonics Conference. Virtual.
- Kang, D. (2019, April). Light sheet microscopy of human skin in vivo. OSA Biophotonics Congress.
- Kang, D. (2019, April). Low-cost, high-speed near-infrared confocal microscope. OSA Biophotonics Congress.
- Kang, D. (2019, February). Artifact correction and automated eosinophil counting for SECM tethered capsule endomicroscopy. Photonics West.
- Kang, D. (2019, February). Evaluating fibrin polymerization dynamics in three dimensions peri-operatively in cardiac surgical patients using spectrally encoded confocal microscopy (SECM). Photonics West.
- Kang, D. (2019, February). High-speed spectrally encoded confocal microscopy (SECM) using 100-kHz swept source laser. Photonics West.
- Kang, D. (2019, February). Implementation of a Portable Confocal Microscope to Diagnose Kaposi’s Sarcoma: The Challenge of Point-of-Care Diagnostics for Skin of Color in Low Resource Settings. Skin of Color Society (SOCS) 15th Annual Scientific Symposium.
- Kang, D. (2019, February). Low-cost, smartphone confocal microscope. Photonics West.
- Kang, D. (2019, February). Preclinical swine joint imaging using forward-viewing spectrally encoded endoscopy. Photonics West.
- Kang, D. (2019, February). Probe-based video-rate color forward-view spectrally encoded endoscopy,. Photonics West.
- Kang, D. (2019, February). Smartphone confocal microscopy for imaging Kaposi’s sarcoma in low-resource settings. Photonics West.
- Kang, D. (2019, June). NOVEL POINT OF CARE DIAGNOSTIC STRATEGIES FOR SKIN DISEASE IN LOW RESOURCE SETTINGS: PORTABLE CONFOCAL MICROSCOPY FOR KAPOSI’S SARCOMA. 24th World Congress of Dermatology.
- Kang, D. (2019, May). AUTOMATED DIAGNOSIS OF EOSINOPHILIC ESOPHAGITIS FROM LARGE IMAGES OBTAINED BY SPECTRALLY-ENCODED TETHERED CAPSULE REFLECTANCE ENDOMICROSCOPY. Digestive Diseases Week.
Awards
- Clinical Research Day Award
- Massachusetts General Hospital, Fall 2018
- Mentor Award
- Harvard-MIT summer institute at MGH, Summer I 2016
- Poster Exhibition Winner
- Dermatology Entrepreneurship Conference, Spring 2015