Elizabeth Hutchinson

Assistant Professor of Biomedical Engineering
Elizabeth Hutchinson

Bioscience Research Labs 321

hutchinsone@arizona.edu

Dr. Elizabeth Hutchinson is an assistant professor in the department of Biomedical Engineering at the University of Arizona and leads the multi-scale brain imaging lab, which uses pre-clinical imaging – especially MRI – to better understand brain disorders and develop translationally relevant imaging markers. Dr. Hutchinson has an educational background in the physical sciences and neuroscience and her research interests include neuroimaging and pre-clinical models of brain disorders. She has contributed primarily in the areas of diffusion MRI methods and traumatic brain injury (TBI) models and in her work has identified several novel markers of brain pathology that follow brain trauma. Within these broad research areas, her research interests include: radiologic-pathologic correspondence studies to associate imaging markers with their biological underpinnings, the development of processing and analysis tools for multi-brain studies, the identification of imaging markers in human-similar models of injury and fixed specimen studies to establish the translational relevance of novel imaging markers. Her current research activities continue to explore and apply advanced neuroimaging approaches through the use of translationally relevant models and pre-clinical neuroimaging across a range of spatial scales and modalities. 

Degrees

  • PhD Neuroscience
    • University of Wisconsin, Madison, Wisconsin, United States
    • Diffusion tensor imaging of central nervous system abnormalities with an emphasis on epilepsy
  • BS Physics
    • The Pennsylvania State University, University Park, Pennsylvania, United States

Work Experience

  • NIH (2016 - 2019)
  • NIH (2012 - 2016)
  • University of Wisconsin, Madison, Wisconsin (2009 - 2012)

Interests

Teaching

MRI methods, Neuroscience

Research

Magnetic Resonance Imaging, Pre-clinical rodent and ferret models, Traumatic, Brain Injury, Epilepsy, Diffusion MRI

Courses

Intro to Programming for BME

BME 225 (Fall 2024)
BME 225 (Fall 2023)
BME 225 (Fall 2022)
 

Honors Independent Study

ECOL 299H (Spring 2023)
 

Biomedical Imaging

BME 416 (Spring 2024)
BME 416 (Spring 2023)
BME 416 (Spring 2022)
BME 416 (Spring 2021)
BME 416 (Spring 2020)
 

Directed Research

BME 492 (Spring 2023)
BME 492 (Fall 2022)
BME 492 (Spring 2022)
BME 492 (Fall 2021)
 

Honors Thesis

ECOL 498H (Spring 2023)
ECOL 498H (Fall 2022)
PSIO 498H (Fall 2024)
 

Rsrch Meth Biomed Engr

BME 592 (Fall 2023)
BME 592 (Spring 2023)
BME 592 (Fall 2022)
BME 592 (Fall 2021)
BME 592 (Fall 2020)
BME 597G (Fall 2019)
 

Advanced Medical Imaging

OPTI 638 (Spring 2023)
 

Biomedical Engr Seminar

BME 696A (Fall 2022)
BME 696A (Fall 2021)
 

Bme Student Forum

BME 696C (Spring 2023)
BME 696C (Spring 2022)
 

Master's Report

BME 909 (Spring 2022)
 

Thesis

BME 910 (Spring 2024)
BME 910 (Fall 2023)
BME 910 (Spring 2023)
OPTI 910 (Fall 2022)
OPTI 910 (Spring 2022)
 

Dissertation

BME 920 (Fall 2024)
BME 920 (Spring 2024)
BME 920 (Fall 2023)
BME 920 (Spring 2023)
BME 920 (Fall 2022)
BME 920 (Spring 2022)
BME 920 (Fall 2021)
BME 920 (Spring 2021)

Selected Publications

Journals/Publications

  • Berry, D. B., Galinsky, V. L., Hutchinson, E. B., Galons, J. P., Ward, S. R., & Frank, L. R. (2023). Double pulsed field gradient diffusion MRI to assess skeletal muscle microstructure. Magnetic resonance in medicine, 90(4), 1582-1593.
  • , A. K., , L. D., , E. C., , C. A., , R. S., , P. W., , E. B., & , K. L. (2022). Hyperacute pathophysiology of traumatic and vascular brain injury captured by ultrasound, photoacoustic, and magnetic resonance imaging.
  • Hutchinson, E. B., Pierpaoli, C., Dardzinski, B. J., Juliano, S. L., Schwerin, S. C., King, S. G., Shunmugavel, A., Korotcov, A., Bosomtwi, A., Knutsen, A. K., Johnson, H. R., & Romero-Lozano, A. (2022). Translationally Relevant Magnetic Resonance Imaging Markers in a Ferret Model of Closed Head Injury. Frontiers in Neuroscience. doi:10.3389/fnins.2021.779533
  • Hutchinson, E. B., Romero-Lozano, A., Johnson, H. R., Knutsen, A. K., Bosomtwi, A., Korotcov, A., Shunmugavel, A., King, S. G., Schwerin, S. C., Juliano, S. L., Dardzinski, B. J., & Pierpaoli, C. (2021). Translationally Relevant Magnetic Resonance Imaging Markers in a Ferret Model of Closed Head Injury. Frontiers in neuroscience, 15, 779533.
  • Hutchinson, E., Osting, S., Rutecki, P., & Sutula, T. (2021). Diffusion Tensor Orientation as a Microstructural MRI Marker of Mossy Fiber Sprouting After TBI in Rats. Journal of neuropathology and experimental neurology.
  • Kishimoto, A. O., Kishimoto, Y., Shi, X., Hutchinson, E. B., Zhang, H., Shi, Y., Oliveira, G., Li, L., Welham, N. V., & Rowland, I. J. (2021). High-resolution magnetic resonance and mass spectrometry imaging of the human larynx. Journal of anatomy, 239(3), 545-556.
  • Schwerin, S. C., Chatterjee, M., Hutchinson, E. B., Djankpa, F. T., Armstrong, R. C., McCabe, J. T., Perl, D. P., & Juliano, S. L. (2021). Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets. Journal of neuropathology and experimental neurology, 80(2), 112-128.
  • Benjamini, D., Hutchinson, E. B., Komlosh, M. E., Comrie, C. J., Schwerin, S. C., Zhang, G., Pierpaoli, C., & Basser, P. J. (2020). Direct and specific assessment of axonal injury and spinal cord microenvironments using diffusion correlation imaging. NeuroImage, 221, 117195.
  • Hutchinson, E. B., Basser, P. J., Pierpaoli, C., Zhang, G., Schwerin, S. C., Comrie, C. J., Komlosh, M. E., & Benjamini, D. (2020). Direct and specific assessment of axonal injury and spinal cord microenvironments using diffusion correlation imaging. bioRxiv. doi:10.1101/2020.05.04.074856
  • Sadeghi, N., Hutchinson, E., Van Ryzin, C., FitzGibbon, E. J., Butman, J. A., Webb, B. D., Facio, F., Brooks, B. P., Collins, F. S., Jabs, E. W., Engle, E. C., Manoli, I., Pierpaoli, C., & , M. S. (2020). Brain phenotyping in Moebius syndrome and other congenital facial weakness disorders by diffusion MRI morphometry. Brain communications, 2(1), fcaa014.
  • Sadeghi, N., Hutchinson, E., Van, R. C., FitzGibbon, E. J., Butman, J. A., Webb, B. D., Facio, F., Brooks, B. P., Collins, F. S., Jabs, E. W., & others, . (2020). Brain phenotyping in Moebius syndrome and other congenital facial weakness disorders by diffusion MRI morphometry. Brain Communications.
  • Han, T. U., Root, J., Reyes, L. D., Huchinson, E. B., Hoffmann, J. D., Lee, W. S., Barnes, T. D., & Drayna, D. (2019). Human stuttering mutations engineered into mice cause vocalization deficits and astrocyte pathology in the corpus callosum. Proceedings of the National Academy of Sciences of the United States of America, 116(35), 17515-17524.
  • Hutchinson, E. B., Chatterjee, M., Reyes, L., Djankpa, F. T., Valiant, W. G., Dardzinski, B., Mattapallil, J. J., Pierpaoli, C., & Juliano, S. L. (2019). The effect of Zika virus infection in the ferret. The Journal of comparative neurology, 527(10), 1706-1719.
  • Komlosh, M. E., Benjamini, D., Williamson, N. W., Horkay, F., Hutchinson, E. B., & Basser, P. J. (2019). A novel MRI phantom to study interstitial fluid transport in the glymphatic system. Magnetic resonance imaging, 56, 181-186.
  • Avram, A. V., Sarlls, J. E., Hutchinson, E., & Basser, P. J. (2018). Efficient experimental designs for isotropic generalized diffusion tensor MRI (IGDTI). Magnetic resonance in medicine, 79(1), 180-194.

Proceedings Publications

  • Dieckhaus, L. A., Comrie, C. J., McDermott, K. E., Gray, D. T., Barnes, C. A., & Hutchinson, E. B. (2022, May). Beyond Fractional Anisotropy: A Comparative Study of Myelin Water Fraction and Propagator Anisotropy in the Bonnet Macaque Brain. In International Society for Magnetic Resonance in Medicine.
  • Bilgin, A., Do, L., Martin, P. A., Lockhart, E., Bernstein, A. S., Ugonna, C., Dieckhaus, L., Comrie, C., Hutchinson, E. B., Chen, N., Alexander, G. E., Barnes, C. A., & Trouard, T. P. (2021). Accelerating Diffusion Tensor Imaging of the Rat Brain using Deep Learning. In Annual Meeting of the International Society for Magnetic Resonance in Medicine.
  • Dieckhaus, L. A., McDermott, K. E., Gray, D. T., Hutchinson, E. B., & Barnes, C. A. (2021, Fall). MRI micro- and macrostructural biomarkers linked to nonpathological brain aging in macaques. In Society for Neuroscience.
  • Galons, J., Harkins, K., Does, M., Trouard, T. P., & Hutchinson, E. B. (2020, April). Quantitative myelin imaging in the ferret brain for traumatic brain injury research. In International Society for Magnetic Resonance in Medicine.
  • Hutchinson, E. B., Gangoli, M., McKee, A., Kim, J., Pajevic, S., & Basser, P. J. (2020, April). Correspondence of diffusion tensor and propagator metrics with quantitative histologic outcomes in chronic traumatic encephalopathy. In International Society for Magnetic Resonance in Medicine.
  • Kamali, A., Dieckhaus, L. A., Peters, E., Hutchinson, E. B., Laksari, K., & Pires, P. (2021, Oct.). The Golden Hour: Early outcomes of traumatic brain injury and stroke. In Biomedical Engineering Society.
  • Jenkins, J., Chang, L., Irfanoglu, M. O., Pierpaoli, C., & Hutchinson, E. B. (2016). Harmonization of methods to facilitate reproducibility in medical data processing: Applications to diffusion tensor magnetic resonance imaging. In 2016 IEEE International Conference on Big Data (Big Data), 3992-3994.

Presentations

  • Hutchinson, E. B. (2021, Fall). Microstructural MRI validation and translational studies to improve detection of neuropathology following brain injury. BrainMap SeminarMartinos Center, MGH.
  • Hutchinson, E. B., Pires, P., & Witte, R. S. (2021, Feb.). Mouse Brain Photoacoustic Imaging to Detect Hyper-Acute Pathophysiology Following Traumatic Brain Injury, Ischemia and Hemorrhage.. VisualSonics Live Imaging Workshop: “From Brain to Belly”VisualSonics.