Associate Professor of Biomedical Engineering
Nan-kuei Chen is an magnetic resonance imaging (MRI) scientist with extensive expertise in MRI physics, fast MR image acquisition methodology, pulse sequence design, signal processing, and MRI artifact correction. He has developed novel approaches to effectively address various types of challenging MRI artifacts, ranging from echo-planar imaging (EPI) distortions, to susceptibility effect induced signal loss, to EPI Nyquist artifact, to motion-induced phase errors and aliasing artifacts in interleaved EPI based diffusion-weighted imaging. Nan-kuei Chen is the original developer of multiplexed sensitivity encoded (MUSE) MRI, which can measure human brain connectivity in vivo at high spatial-resolution and accuracy. The current focus of his research is the development of innovative data acquisition and reconstruction approaches to enable high-resolution, artifact-free, multi-contrast and quantitative MR imaging for challenging patients within a clinically-feasible time period. Nan-kuei Chen has been serving as PI on NIH-funded R01, R21 and R03 grants, and has had extensive experience as a co-investigator on NIH-funded projects.
- Ph.D. Biomedical Engineering
- Northwestern University, Evanston, Illinois, United States
- Duke University (2016 - Ongoing)
- University of Arizona (2016 - Ongoing)
- Duke University (2007 - 2016)
- Harvard Medical School (2005 - 2007)
Medical Imaging; Magnetic Resonance Imaging;
1) Development of high-throughput and motion-immune clinical MRI for imaging challenging patient populations2) Imaging of neuronal connectivity networks for studies of neurological diseases3) High-fidelity and multi-contrast MRI guided intervention4) Characterization and correction of MRI artifacts5) Signal processing and algorithm development6) MRI studies of human development
Honors Independent Study
NSCS 399H (Fall 2018)
BME 492 (Spring 2019)
BME 492 (Fall 2018)
BME 492 (Spring 2018)
BME 492 (Fall 2017)
Rsrch Meth Biomed Engr
BME 597G (Spring 2018)
BME 597G (Fall 2017)
Magnetic Resonance Imaging
BME 639 (Spring 2018)
- Bell, R. P., Barnes, L. L., Towe, S. L., Chen, N. K., Song, A. W., & Meade, C. S. (2018). Structural connectome differences in HIV infection: brain network segregation associated with nadir CD4 cell count. Journal of neurovirology, 24(4), 454-463.
- Chen, N. K., Chang, H. C., Bilgin, A., Bernstein, A., & Trouard, T. P. (2018). A diffusion-matched principal component analysis (DM-PCA) based two-channel denoising procedure for high-resolution diffusion-weighted MRI. PloS one, 13(4), e0195952.
- Chen, N. K., Chou, Y. H., Sundman, M., Hickey, P., Kasoff, W. S., Bernstein, A., Trouard, T. P., Lin, T., Rapcsak, S. Z., Sherman, S. J., & Weingarten, C. P. (2018). Alteration of Diffusion-Tensor Magnetic Resonance Imaging Measures in Brain Regions Involved in Early Stages of Parkinson's Disease. Brain connectivity, 8(6), 343-349.
- Chu, M. L., Chang, H. C., Chung, H. W., Bashir, M. R., Cai, J., Zhang, L., Sun, D., & Chen, N. K. (2018). Free-breathing abdominal MRI improved by repeated k-t-subsampling and artifact-minimization (ReKAM). Medical physics, 45(1), 178-190.
- Chu, M. L., Chang, H. C., Oshio, K., & Chen, N. K. (2018). A single-shot T2 mapping protocol based on echo-split gradient-spin-echo acquisition and parametric multiplexed sensitivity encoding based on projection onto convex sets reconstruction. Magnetic resonance in medicine, 79(1), 383-393.
- Horne, A. J., Chiew, K. S., Zhuang, J., George, L. K., Adcock, R. A., Potter, G. G., Lad, E. M., Cousins, S. W., Lin, F. R., Mamo, S. K., Chen, N. K., Maciejewski, A. J., Duong Fernandez, X., & Whitson, H. E. (2018). Relating Sensory, Cognitive, and Neural Factors to Older Persons' Perceptions about Happiness: An Exploratory Study. Journal of aging research, 2018, 4930385.
- Meade, C. S., Addicott, M., Hobkirk, A. L., Towe, S. L., Chen, N. K., Sridharan, S., & Huettel, S. A. (2018). Cocaine and HIV are independently associated with neural activation in response to gain and loss valuation during economic risky choice. Addiction biology, 23(2), 796-809.
- Meade, C. S., Bell, R. P., Towe, S. L., Chen, N. K., Hobkirk, A. L., & Huettel, S. A. (2018). Synergistic effects of marijuana abuse and HIV infection on neural activation during a cognitive interference task. Addiction biology.
- Sonderer, C. M., & Chen, N. K. (2018). Improving the Accuracy, Quality, and Signal-To-Noise Ratio of MRI Parametric Mapping Using Rician Bias Correction and Parametric-Contrast-Matched Principal Component Analysis (PCM-PCA). The Yale journal of biology and medicine, 91(3), 207-214.
- Zhuang, J., Madden, D. J., Duong-Fernandez, X., Chen, N. K., Cousins, S. W., Potter, G. G., Diaz, M. T., & Whitson, H. E. (2018). Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere. Neurobiology of aging, 63, 65-74.
- Bruce, I. P., Chang, H. C., Petty, C., Chen, N. K., & Song, A. W. (2017). 3D-MB-MUSE: A robust 3D multi-slab, multi-band and multi-shot reconstruction approach for ultrahigh resolution diffusion MRI. NeuroImage, 159, 46-56.
- Chang, H. C., Hui, E. S., Chiu, P. W., Liu, X., & Chen, N. K. (2017). Phase correction for three-dimensional (3D) diffusion-weighted interleaved EPI using 3D multiplexed sensitivity encoding and reconstruction (3D-MUSER). Magnetic resonance in medicine.
- Cordero, D. M., Towe, S. L., Chen, N. K., Robertson, K. R., Madden, D. J., Huettel, S. A., & Meade, C. S. (2017). Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. Journal of neurovirology, 23(3), 441-450.
- Madden, D. J., Parks, E. L., Tallman, C. W., Boylan, M. A., Hoagey, D. A., Cocjin, S. B., Packard, L. E., Johnson, M. A., Chou, Y. H., Potter, G. G., Chen, N. K., Siciliano, R. E., Monge, Z. A., Honig, J. A., & Diaz, M. T. (2017). Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. Neurobiology of aging, 54, 199-213.
- Meade, C. S., Hobkirk, A. L., Towe, S. L., Chen, N. K., Bell, R. P., & Huettel, S. A. (2017). Cocaine dependence modulates the effect of HIV infection on brain activation during intertemporal decision making. Drug and alcohol dependence, 178, 443-451.
- Bernstein, A., Chen, N., & Trouard, T. P. (2018, June). A Bootstrap Analysis of Diffusion MRI Parameters Derived from Simultaneous Multislice Diffusion MRI. In Joint International Society for Magnetic Resonance in Medicine & The European Society for Magnetic Resonance in Medicine and Biology (ISMRM-ESMRMB) Annual Meeting.
- Chen, N., Chen, N., Chang, H. C., Chang, H. C., Bilgin, A., Bilgin, A., Bernstein, A., Bernstein, A., Trouard, T. P., Trouard, T. P., Chen, N., Chang, H. C., Bilgin, A., Bernstein, A., & Trouard, T. P. (2018, June). A diffusion-matched principal component analysis (DM-PCA) based denoising procedure for high-resolution diffusion-weighted MRI. In Joint International Society for Magnetic Resonance in Medicine & The European Society for Magnetic Resonance in Medicine and Biology (ISMRM-ESMRMB) Annual Meeting.
- Lindley, M., Bernstein, A., Ugonna, C., Bruck, D., Johnson, K., Altbach, M. I., Ryan, L., Chen, N., Chou, Y., Guzman Perez-Carrillo, G., Trouard, T. P., & Weinkauf, C. C. (2018, June). Impact of Carotid Endarterectomy on Functional Connectivity. In Joint International Society for Magnetic Resonance in Medicine & The European Society for Magnetic Resonance in Medicine and Biology (ISMRM-ESMRMB) Annual Meeting, 5562.
- Award for Xsede startup research
- Extreme Science and Engineering Discover Environment (XSEDE.org), Fall 2016