Associate Professor of Biomedical Engineering
Nan-kuei Chen is an magnetic resonance imaging (MRI) scientist with extensive expertise in MRI physics, fast MR image acquisition methodology, pulse sequence design, signal processing, and MRI artifact correction. He has developed novel approaches to effectively address various types of challenging MRI artifacts, ranging from echo-planar imaging (EPI) distortions, to susceptibility effect induced signal loss, to EPI Nyquist artifact, to motion-induced phase errors and aliasing artifacts in interleaved EPI based diffusion-weighted imaging. Nan-kuei Chen is the original developer of multiplexed sensitivity encoded (MUSE) MRI, which can measure human brain connectivity in vivo at high spatial-resolution and accuracy. The current focus of his research is the development of innovative data acquisition and reconstruction approaches to enable high-resolution, artifact-free, multi-contrast and quantitative MR imaging for challenging patients within a clinically-feasible time period. Nan-kuei Chen has been serving as PI on NIH-funded R01, R21 and R03 grants, and has had extensive experience as a co-investigator on NIH-funded projects.
- Ph.D. Biomedical Engineering
- Northwestern University, Evanston, Illinois, United States
- Adjunct Associate Professor, Duke University (2016 - Ongoing)
- Associate Professor, University of Arizona (2016 - Ongoing)
- Associate Professor, Duke University (2007 - 2016)
- Assistant Professor, Harvard Medical School (2005 - 2007)
- Award for Xsede startup research
- Extreme Science and Engineering Discover Environment (XSEDE.org), Fall 2016
Medical Imaging; Magnetic Resonance Imaging;
1) Development of high-throughput and motion-immune clinical MRI for imaging challenging patient populations2) Imaging of neuronal connectivity networks for studies of neurological diseases3) High-fidelity and multi-contrast MRI guided intervention4) Characterization and correction of MRI artifacts5) Signal processing and algorithm development6) MRI studies of human development
BME 492 (Spring 2018)
BME 492 (Fall 2017)
Magnetic Resonance Imaging
BME 639 (Spring 2018)
Rsrch Meth Biomed Engr
BME 597G (Spring 2018)
BME 597G (Fall 2017)
- Bruce, I. P., Chang, H. C., Petty, C., Chen, N. K., & Song, A. W. (2017). 3D-MB-MUSE: A robust 3D multi-slab, multi-band and multi-shot reconstruction approach for ultrahigh resolution diffusion MRI. NeuroImage, 159, 46-56.
- Chang, H. C., Hui, E. S., Chiu, P. W., Liu, X., & Chen, N. K. (2017). Phase correction for three-dimensional (3D) diffusion-weighted interleaved EPI using 3D multiplexed sensitivity encoding and reconstruction (3D-MUSER). Magnetic resonance in medicine.
- Chu, M. L., Chang, H. C., Chung, H. W., Bashir, M. R., Cai, J., Zhang, L., Sun, D., & Chen, N. K. (2018). Free-breathing abdominal MRI improved by repeated k-t-subsampling and artifact-minimization (ReKAM). Medical physics, 45(1), 178-190.
- Chu, M. L., Chang, H. C., Oshio, K., & Chen, N. K. (2018). A single-shot Tmapping protocol based on echo-split gradient-spin-echo acquisition and parametric multiplexed sensitivity encoding based on projection onto convex sets reconstruction. Magnetic resonance in medicine, 79(1), 383-393.
- Cordero, D. M., Towe, S. L., Chen, N. K., Robertson, K. R., Madden, D. J., Huettel, S. A., & Meade, C. S. (2017). Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. Journal of neurovirology, 23(3), 441-450.
- Madden, D. J., Parks, E. L., Tallman, C. W., Boylan, M. A., Hoagey, D. A., Cocjin, S. B., Packard, L. E., Johnson, M. A., Chou, Y. H., Potter, G. G., Chen, N. K., Siciliano, R. E., Monge, Z. A., Honig, J. A., & Diaz, M. T. (2017). Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. Neurobiology of aging, 54, 199-213.
- Meade, C. S., Addicott, M., Hobkirk, A. L., Towe, S. L., Chen, N. K., Sridharan, S., & Huettel, S. A. (2018). Cocaine and HIV are independently associated with neural activation in response to gain and loss valuation during economic risky choice. Addiction biology, 23(2), 796-809.
- Meade, C. S., Hobkirk, A. L., Towe, S. L., Chen, N. K., Bell, R. P., & Huettel, S. A. (2017). Cocaine dependence modulates the effect of HIV infection on brain activation during intertemporal decision making. Drug and alcohol dependence, 178, 443-451.
- Sundman, M. H., Chen, N. K., Subbian, V., & Chou, Y. H. (2017). The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease. Brain, behavior, and immunity, 66, 31-44.
- Zhuang, J., Madden, D. J., Duong-Fernandez, X., Chen, N. K., Cousins, S. W., Potter, G. G., Diaz, M. T., & Whitson, H. E. (2018). Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere. Neurobiology of aging, 63, 65-74.
- Chang, H., & Chen, N. (2016). Joint correction of Nyquist artifact and minuscule motion-induced aliasing artifact in interleaved diffusion weighted EPI data using a composite two-dimensional phase correction procedure. Magnetic resonance imaging, 34(7), 974-9.
- Chou, Y. H., Sundman, M., Whitson, H. E., Gaur, P., Chu, M. L., Weingarten, C. P., Madden, D. J., Wang, L., Kirste, I., Joliot, M., Diaz, M. T., Li, Y. J., Song, A. W., & Chen, N. K. (2017). Maintenance and Representation of Mind Wandering during Resting-State fMRI. Scientific reports, 7, 40722.
- Guhaniyogi, S., Chu, M., Chang, H., Song, A. W., & Chen, N. (2016). Motion immune diffusion imaging using augmented MUSE for high-resolution multi-shot EPI. Magnetic resonance in medicine, 75(2), 639-52.
- MacInnes, J. J., Dickerson, K. C., Chen, N., & Adcock, R. A. (2016). Cognitive Neurostimulation: Learning to Volitionally Sustain Ventral Tegmental Area Activation. Neuron, 89(6), 1331-42.
- Madden, D. J., Parks, E. L., Tallman, C. W., Boylan, M. A., Hoagey, D. A., Cocjin, S. B., Johnson, M. A., Chou, Y. H., Potter, G. G., Chen, N. K., Packard, L. E., Siciliano, R. E., Monge, Z. A., & Diaz, M. T. (2017). Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age. Human brain mapping.