Jil C. Tardiff
Professor of Medicine
Professor of Cellular and Molecular Medicine
Professor, Physiological Sciences Graduate Interdisciplinary Program
Vice Chair of Research, Department of Medicine
Jil Tardiff, MD, PhD, is a professor of medicine and cellular and molecular medicine at the University of Arizona College of Medicine - Tucson and a member of the Clinical and Translational Institute at the BIO5 Institute. She attended the University of California at Berkeley where she completed her B.A. in Genetics in 1984. She subsequently completed her M.D. and a Ph.D. (in Cell Biology) at the Albert Einstein College of Medicine in New York City in 1992. Dr. Tardiff pursued her housestaff training at Columbia-Presbyterian Medical Center in New York City. As one of the first participants in the ABIM Clinician-Scientist pathway as a Markey Fellow, she completed an internal medicine residency coupled to a combined clinical-research fellowship in cardiovascular medicine at Columbia. In 2001 she joined the faculty at the Albert Einstein College of Medicine as an assistant professor of medicine and physiology and biophysics. She remained on faculty at Einstein, achieving the rank of associate professor. In 2012 Dr. Tardiff joined the faculty at the University of Arizona College of Medicine, where she currently holds the Steven M. Gootter Endowed Chair for the Prevention of Sudden Cardiac Death.
As a physician-scientist, Dr. Tardiff’s work focuses on the mechanisms that underlie the development of the most common form of genetic cardiomyopathy, those caused by mutations in proteins of the cardiac sarcomere, hypertrophic cardiomyopathy (HCM). These complex disorders affect one in 500 individuals of all ages and represent the most common cause of sudden cardiac death in the field. Her studies detailing the mechanisms of disease pathogenesis at the level of individual cells using transgenic mouse models has been continuously funded by the NIH since 2001 and the work has been cited in support of new clinical trials to evaluate novel treatment modalities for this challenging cardiomyopathy. More recently, in collaboration with Steven Schwartz in the Department of Chemistry at the University of Arizona, her lab has developed computational approaches to modeling and eventually predicting disease severity based on protein structure. To fully translate these basic research findings to the clinical realm, one of her main goals remains the development of an HCM Center of Excellence at the University of Arizona where patients from all over the southwest can obtain lifelong cutting edge medical care for this complex and often devastating disorder.
Dr. Tardiff was awarded $1.4 million (NIH grant number HL075619) to continue her lab’s study of “Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies.” Hypertrophic Cardiomyopathy is an often devastating and common cardiac genetic disease. The goal of this research is to improve the understanding of how independent mutations cause this complex disorder and discover better therapeutic options, especially in young people.
- Ph.D. Cell Biology
- Albert Einstein College of Medicine, Bronx, New York, United States
- Albert Einstein College of Medicine, Bronx, New York, United States
- B.A. Genetics
- University of California at Berkeley, Berkeley, California, United States
- Professor, University of Arizona, Tucson, Arizona (2012 - Ongoing)
- Associate Professor, Albert Einstein College of Medicine (2008 - 2012)
- Assistant Professor, Albert Einstein College of Medicine (2001 - 2008)
- Instructor in Internal Medicine, Albert Einstein College of Medicine (1998 - 1999)
- New Investigator Award
- AHA Scientific Conference on Molecular, Cellular, and Integrated Physiologic Approaches to the Failing Heart, Summer I 1999
- Research Fellowship
- Markey Foundation, Summer I 1994
- Regent's Scholarship
- University of California at Berkeley, Fall 1980
- American College of Cardiology, Summer I 2011
- American Heart Association, Summer I 2010
- Election to the Leadership Council of the Basic Cardiovascular Sciences
- American Heart Association, Spring 2010
- Election as Chair of Contractile and Regulatory Proteins Interest Group
- ISHR, Fall 2009
- Election to Council
- International Society of Heart Research, Summer I 2009
- Henry Moses Prize for Research Excellence
- Montefiore Medical Center, Fall 2001
- Wyeth-Ayerst Women in Cardiology Award
- American Heart Association, Fall 2000
Licensure & Certification
- Cardiovascular Diseases, American Board of Internal Medicine (2002)
- Internal Medicine, American Board of Internal Medicine (1996)
PS 900 (Spring 2018)
PS 900 (Fall 2017)
PS 900 (Spring 2017)
PS 900 (Fall 2016)
NSCS 399 (Spring 2018)
BME 920 (Spring 2018)
PS 920 (Fall 2017)
BME 920 (Fall 2017)
PS 920 (Spring 2017)
BME 920 (Spring 2017)
PS 920 (Fall 2016)
BME 920 (Fall 2016)
Cardio Muscle Bio & Disease
PSIO 584 (Spring 2018)
PSIO 484 (Spring 2018)
CMM 584 (Spring 2017)
PSIO 484 (Spring 2017)
BME 484 (Spring 2017)
BME 584 (Spring 2017)
PSIO 498H (Spring 2018)
BIOC 498H (Spring 2018)
PSIO 498H (Fall 2017)
BIOC 498H (Fall 2017)
Honors Independent Study
BIOC 499H (Spring 2018)
PSIO 499H (Spring 2017)
BIOC 499H (Spring 2017)
PSIO 399H (Fall 2016)
Rsrch Meth Psio Sci
PS 700 (Fall 2017)
PS 700 (Spring 2017)
PS 700 (Fall 2016)
PS 910 (Spring 2017)
PSIO 492 (Spring 2017)
PSIO 492 (Fall 2016)
BIOC 492 (Fall 2016)
- Coppini, R., Mazzoni, L., Ferrantini, C., Gentile, F., Pioner, J. M., Laurino, A., Santini, L., Bargelli, V., Rotellini, M., Bartolucci, G., Crocini, C., Sacconi, L., Tesi, C., Belardinelli, L., Tardiff, J., Mugelli, A., Olivotto, I., Cerbai, E., & Poggesi, C. (2017). Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy. Circulation. Heart failure, 10(3).
- Ferrantini, C., Coppini, R., Pioner, J. M., Gentile, F., Tosi, B., Mazzoni, L., Scellini, B., Piroddi, N., Laurino, A., Santini, L., Spinelli, V., Sacconi, L., De Tombe, P., Moore, R., Tardiff, J., Mugelli, A., Olivotto, I., Cerbai, E., Tesi, C., & Poggesi, C. (2017). Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models. Journal of the American Heart Association, 6(7).
- Lynn, M. L., Tal Grinspan, L., Holeman, T. A., Jimenez, J., Strom, J., & Tardiff, J. C. (2017). The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy. Journal of molecular and cellular cardiology, 108, 127-137.
- McConnell, M., Tal Grinspan, L., Williams, M. R., Lynn, M. L., Schwartz, B. A., Fass, O. Z., Schwartz, S. D., & Tardiff, J. C. (2017). Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap. Biochemistry, 56(26), 3403-3413.
- Tardiff, J. C. (2017). Assessing the Phenotypic Burden of Preclinical Sarcomeric Hypertrophic Cardiomyopathy-New Assessments to Guide Diagnosis and Management. JAMA cardiology, 2(4), 428-429.
- Behunin, S. M., Lopez-Pier, M. A., Mayfield, R. M., Danilo, C. A., Lipovka, Y., Birch, C., Lehman, S., Tardiff, J. C., Gregorio, C. C., & Konhilas, J. P. (2016). Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes. Archives of biochemistry and biophysics, 601, 32-41.
- Crocini, C., Ferrantini, C., Scardigli, M., Coppini, R., Mazzoni, L., Lazzeri, E., Pioner, J. M., Scellini, B., Guo, A., Song, L. S., Yan, P., Loew, L. M., Tardiff, J., Tesi, C., Vanzi, F., Cerbai, E., Pavone, F. S., Sacconi, L., & Poggesi, C. (2016). Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology, 91, 42-51.
- Jian, Z., Chen, Y. J., Shimkunas, R., Jian, Y., Jaradeh, M., Chavez, K., Chiamvimonvat, N., Tardiff, J. C., Izu, L. T., Ross, R. S., & Chen-Izu, Y. (2016). In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PloS one, 11(8), e0160605.
- Tardiff, J. C. (2016). The Role of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Hypertrophic Cardiomyopathy. Circulation, 134(22), 1749-1751.
- Williams, M. R., Lehman, S. J., Tardiff, J. C., & Schwartz, S. D. (2016). Atomic resolution probe for allostery in the regulatory thin filament. Proceedings of the National Academy of Sciences of the United States of America, 113(12), 3257-62.
- Duncker, D. J., Bakkers, J., Brundel, B. J., Robbins, J., Tardiff, J. C., & Carrier, L. (2015). Animal and in silico models for the study of sarcomeric cardiomyopathies. Cardiovascular research, 105(4), 439-48.
- Gollapudi, S. K., Tardiff, J. C., & Chandra, M. (2015). The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoforms. American journal of physiology. Heart and circulatory physiology, 308(8), H884-93.
- Hill, M. G., Sekhon, M. K., Reed, K. L., Anderson, C. F., Borjon, N. D., Tardiff, J. C., & Barber, B. J. (2015). Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation. Pediatric cardiology, 36(8), 1774-7.
- Sequeira, V., Najafi, A., McConnell, M., Fowler, E. D., Bollen, I. A., Wüst, R. C., dos Remedios, C., Helmes, M., White, E., Stienen, G. J., Tardiff, J., Kuster, D. W., & van der Velden, J. (2015). Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness. The Journal of physiology, 593(17), 3899-916.
- Tardiff, J. C., Carrier, L., Bers, D. M., Poggesi, C., Ferrantini, C., Coppini, R., Maier, L. S., Ashrafian, H., Huke, S., & van der Velden, J. (2015). Targets for therapy in sarcomeric cardiomyopathies. Cardiovascular research, 105(4), 457-70.
- Tardiff, J. C. (2017, December). An Integrative Approach to Hypertrophic Cardiomyopathy. Cardiology Grand Rounds. Seattle: University of Washington College of Medicine, Department of Medicine, Cardiology Division.
- Tardiff, J. C. (2017, December). An Integrative Approach to Sarcomeric Cardiomyopathies. Cardiology Grand Rounds, University of Illinois at Chicago. Chicago: University of Illinois at Chicago College of Medicine, Department of Medicine, Cardiology Division.
- Tardiff, J. C. (2017, December). The Role of Allostery in the Pathogenesis of Sarcomeric Cardiomyopathies: Redefining the Approach to a Complex Disorder. University of Washington Visiting Professorship - Cardiovascular T32. Seattle: University of Washington School of Medicine.
- Tardiff, J. C. (2016, April). From Computational Biophysics to Animal Models: Developing a New Paradigm and Eventual Targeted Treatments for Sarcomeric Cardiomyopathies. Invited Talk. Chicago, IL: Northwestern University Medical School.
- Tardiff, J. C. (2016, June). Integrative Approaches to Linking Genotype to Phenotype in Sarcomeric Cardiomyopathies: Are we there yet?. Biennial Myofilament Meeting - Plenary. Madison, Wisconsin: University of Wisconsin at Madison.
- Tardiff, J. C. (2016, June). Session on Myofilament Proteins in Disease. Cardiac Regulatory Mechanisms Gordon Research Conference. New London, NH: Gordon Research Conferences.
- Tardiff, J. C. (2016, March). From Computational Biophysics to Animal Models: Developing a New Paradigm and Eventual Targeted Treatments for Sarcomeric Cardiomyopathies. Invited talk at Novartis Institutes for BioMedical Research. Boston, MA: Novartis.
- Tardiff, J. C. (2016, Summer). Complex Genetic Cardiomyopathies: from Biophysical Triggers to LV Remodeling. Invited talk. Birmingham, AL: University of Alabama at Birmingham School of Medicine.
- Tardiff, J. C. (2015, Feb). An Integrative Approach to Thin Filament Cardiomyopathies: From Molecular and Computational Biophysics to Mice. Biophysical Society Meeting. Baltimore, MD.
- Tardiff, J. C. (2015, February). From Computational Biophysics to Animal Models: Forging an Integrative Approach to Sarcomeric Cardiomyopathies. Cardiology Ground Rounds. Johns Hopkins Medical School.
- Tardiff, J. C. (2015, June). Cardiac Thin Filament Models: High Resolution Tools for Studying Genetic Cardiomyopathies. International Society for Heart Research. Seattle, Washington: University of Washington, Seattle.
- Tardiff, J. C. (2015, June). Integrative Approaches to Sarcomeric Cardiomyopathies: From Computation to Animal Models. Minnesota Muscle Symposium. Minneapolis, Minnesota: University of Minnesota- Wellstone Muscular Dystrophy Center.
- Tardiff, J. C. (2015, March). Is Hypertrophic Cardiomyopathy Really a "Straightforward" Monogeneic Disorder?. Genetics Ground Rounds. U of A Tucson.
- Tardiff, J. C. (2015, November). From Computational Biophysics to Animal Models: An Integrative Approach to Sarcomeric Cardiomyopathies. Cardiology Research Grand Rounds. Boston, MA: Harvard Medical School, Beth-Israel Deaconess.
- Tardiff, J. C. (2015, October). Dissecting sarcomere function and dysfunction: Calcium Regulation in Hypertrophic Cardiomyopathy. III Florence International Symposium on Advances in Cardiomyopathies. Florence, Italy: University of Florence, European Society of Cardiology.