Russell Witte
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Professor of Medical Imaging
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Professor of Optical Sciences
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Professor of Biomedical Engineering
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Professor, Applied Mathematics Graduate Interdisciplinary Program
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Professor, Neuroscience Graduate Interdisciplinary Program
Russell S. Witte graduated with Honors in Physics (BS, 1993) from University of Arizona and Bioengineering (PhD, 2002) from Arizona State University, where he used electrode arrays to study sensory coding and learning-induced plasticity in the brain. As a postdoctoral fellow at the University of Michigan, he helped devise state-of-the-art techniques to image the nervous and musculoskeletal systems. Dr. Witte is now Associate Professor of Medical Imaging, Biomedical Engineering, and Optical Sciences at the University of Arizona. His Experimental Ultrasound and Neural Imaging Laboratory (EUNIL) devises hybrid imaging methods that integrate light, ultrasound, and microwaves for advanced imaging with novel contrast. These noninvasive techniques, such as acoustoelectric imaging, thermoacoustic imaging, and ultrasound elastography, quantify changes in the electrical, optical and/or mechanical properties of tissue at high spatial resolution. The ultimate goal of Dr. Witte’s research is to improve patient care by providing tools that improve diagnostic accuracy and treatment-decision making for a variety of conditions ranging from epilepsy and arrhythmia to tendinopathy and cancer.
Degrees
- Ph.D. Biomedical Engineering
- Arizona State Univeristy, Tempe, Arizona, United States
- Micro-electrode investigation of neural coding and learning-induced plasticity in auditory cortex
Interests
Teaching
• Ultrasound imaging• Functional Brain Imaging • Neural engineering• Bioelectricity ("The Body Electric")• Electromedicine/Vibrational Medicine
Research
• Hybrid modalities that combine ultrasound with light, microwaves and other forms of energy for novel contrast in biomedical imaging• Acoustoelectric Imaging for dynamic mapping of current densities in the heart and brain• Remote temperature mapping during thermal therapy• High resolution functional brain imaging • Photoacoustic imaging and spectroscopy for lymphatic imaging and tumor monitoring• Ultrasound elasticity imaging of human muscle and tendon• Novel acoustic sensors for medical applications
Courses
Honors Independent Study
BME 299H (Spring 2018)
Directed Research
BME 492 (Fall 2017)
Cnrtst Agnt Imaging+Kint
BME 522 (Spring 2021)
BME 522 (Spring 2020)
BME 522 (Spring 2019)
BME 524 (Spring 2018)
BME 524 (Spring 2017)
BME 524 (Spring 2016)
CBIO 522 (Spring 2020)
CBIO 524 (Spring 2017)
CBIO 524 (Spring 2016)
OPTI 522 (Spring 2021)
OPTI 522 (Spring 2020)
Rsrch Meth Biomed Engr
BME 592 (Fall 2021)
BME 592 (Fall 2020)
BME 597G (Fall 2018)
BME 597G (Fall 2017)
BME 597G (Spring 2017)
Independent Study
BME 599 (Spring 2018)
BME 599 (Fall 2017)
Advanced Medical Imaging
BME 638 (Spring 2018)
BME 638 (Spring 2016)
OPTI 638 (Spring 2021)
OPTI 638 (Spring 2019)
OPTI 638 (Spring 2018)
OPTI 638 (Spring 2016)
Biomedical Engr Seminar
BME 696A (Fall 2021)
BME 696A (Fall 2020)
Bme Student Forum
BME 696C (Spring 2021)
Directed Graduate Research
OPTI 792 (Spring 2020)
OPTI 792 (Fall 2019)
Research
BME 900 (Fall 2020)
Thesis
BME 910 (Fall 2021)
BME 910 (Spring 2021)
Dissertation
BME 920 (Spring 2021)
BME 920 (Fall 2020)
BME 920 (Spring 2020)
BME 920 (Fall 2019)
BME 920 (Spring 2019)
BME 920 (Fall 2018)
OPTI 920 (Fall 2021)
OPTI 920 (Spring 2021)
OPTI 920 (Fall 2020)
Selected Publications
Journals/Publications
- Alvarez, A., Preston, C., Trujillo, T., Wilhite, C., Burton, A., Vohnout, S., & Witte, R. S. (2020). In vivo acoustoelectric imaging for high-resolution visualization of cardiac electric spatiotemporal dynamics. Applied optics, 59(36), 11292-11300.
- Barragan, A., Preston, C., Alvarez, A., Bera, T., Qin, Y., Weinand, M., Kasoff, W., & Witte, R. S. (2020). Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy. Journal of neural engineering, 17(5), 056040.
- Karunakaran, C., Zhao, H., Xin, H., & Witte, R. S. (2020). Real-time Volumetric Thermoacoustic Imaging and Thermometry using a 1.5D Ultrasound Array. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, PP.
- Preston, C., Alvarez, A. M., Barragan, A., Becker, J., Kasoff, W. S., & Witte, R. S. (2020). High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator. Journal of neural engineering, 17(1), 016074.
- Tamimi, E. A., Xin, H., & Witte, R. S. (2020). Real-time 3D thermoacoustic imaging and thermometry using a self-calibration technique. Applied optics, 59(22), G255-G261.
- Wang, X., Qin, T., Witte, R. S., & Xin, H. (2017). Microwave-Induced Thermoacoustic Communications. IEEE Transactions on Microwave Theory and Techniques, 65(9), 3369-78.
- Chinyere, I., Weigand, K., Moukabary, T., Witte, R. S., Lancaster, J., Goldman, S., & Juneman, E. B. (2016). Model of Induced Ventricular Tachycardia and Cardiac Electrophysiological Mapping. Circulation Research, 119(Supl 1), A 71.
- Gao, L., Schmitz, H. A., Zuniga, A. A., Klewer, J. A., Szivek, J. A., Taljanovic, M. S., Latt, L. D., & Witte, R. S. (2016). Minimizing strain error for in vivo ultra-sound elasticity imaging of human tendon. 2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS).
- Gimber, L. H., Melville, D. M., Klauser, A. S., Witte, R. S., Arif-Tiwari, H., & Taljanovic, M. S. (2016). Artifacts at Musculoskeletal US: Resident and Fellow Education Feature. Radiographics : a review publication of the Radiological Society of North America, Inc, 36(2), 479-80.
- Klewer, J., Gao, L., Guerra, J., Szivek, J., Taljanovic, M., Latt, L., & Witte, R. (2016). IN VIVO ULTRASOUND ELASTICITY IMAGING CLASSIFIES HEALTHY AND DISEASED POSTERIOR TIBIAL TENDONS. JOURNAL OF INVESTIGATIVE MEDICINE, 64(1), 324-324.
- Marshalek, J. P., Sheeran, P. S., Ingram, P., Dayton, P. A., Witte, R. S., & Matsunaga, T. O. (2016). Intracellular delivery and ultrasonic activation of folate receptor-targeted phase-change contrast agents in breast cancer cells in vitro. Journal of controlled release : official journal of the Controlled Release Society, 243, 69-77.
- Peyman, G. A., Ingram, C. P., Montilla, L. G., & Witte, R. S. (2016). A high-resolution 3D ultrasonic system for rapid evaluation of the anterior and posterior segment. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye, 43(2), 143-51.
- Qin, Y., Ingram, P., Burton, A., & Witte, R. S. (2016). 4D Acoustoelectric Imaging of Current Sources in a Human Head Phantom. 2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS).
- Wang, X., Witte, R. S., & Xin, H. (2016). Thermoacoustic and photoacoustic characterizations of few-layer graphene by pulsed excitations. APPLIED PHYSICS LETTERS, 108(14).
- Wang, Z., Challoo, R., Peng, H., Leung, C. S., & Witte, R. S. (2016). Complementary Detection of Multiple Electrical Sources in Tissue Using Acoustoelectric Effects. Ultrasound in medicine & biology, 42(9), 2323-33.
Proceedings Publications
- Furdella, K., Witte, R. S., & Vande Geest, J. (2015, Summer). Tracking Mass Transport of a Drug Surrogate in Porcine Coronary Tissue using Photoacoustic Imaging and Spectroscopy. In Biomechanics, Bioengineering and Biotransport Conference.
- Qin, Y., Ingram, P., Wang, X., Qin, T., Xin, H., & Witte, R. S. (2014, 2014). Non-contact thermoacoustic imaging based on laser and microwave vibrometry. In 2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 1033-1036.
- Wang, X., Bauer, D., Witte, R., Xin, H., & , . (2015, 2013). Impact of Microwave Pulses on Microwave-Induced Thermoacoustic Imaging Applications. In 2013 USNC-URSI RADIO SCIENCE MEETING (JOINT WITH AP-S SYMPOSIUM), 210-210.
- Wang, X., Liang, M., Witte, R. S., & Xin, H. (2015, Summer). Fabrication of a realistic breast phantom based on 3D printing technology for thermoacoustic imaging application in breast cancer detection. In USNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 314.
- Wang, X., Witte, R. S., Liang, M., & Xin, H. (2015, Summer). Modeling of non-contact thermoacoustic imaging. In Proceedings IEEE, USNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 17.
- Witte, R. S., Wang, X., Xin, H., & Qin, T. (2015, March). Compressive sensing based contrast-enhanced thermoacoustic imaging for breast cancer detection. In 2015 31st International Review of Progress in Applied Computational Electromagnetics (ACES), 1-2.
- Bauer, D. R., Wang, X., Vollin, J., Xin, H., Witte, R. S., & , . (2014, 2012). Thermoacoustic Imaging and Spectroscopy for Enhanced Breast Cancer Detection. In 2011 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2364-2367.
- Huang, S., Rubin, J. M., Jia, C., Olafsson, R., Witte, R. S., O'Donnell, M., & , . (2014, 2007). Error analysis of axial displacement estimation in elasticity imaging. In 2007 IEEE ULTRASONICS SYMPOSIUM PROCEEDINGS, VOLS 1-6, 1969-1972.
- Panchangam, A., Witte, R. S., Claflin, D. R., O'Donnell, M., Faulkner, J. A., Farkas, D., Nicolau, D., & Leif, R. (2014, 2006). A novel optical imaging system for investigating sarcomere dynamics in single skeletal muscle fibers - art. no. 608808. In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IV, 6088, 8808-8808.
- Qin, T., Wang, X., Meng, H., Qin, Y., Wan, G., Witte, R. S., Xin, H., & , . (2014, 2014). Performance Improvement for Thermoacoustic Imaging Using Compressive Sensing. In 2014 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI), 1919-1920.
- Qin, Y., Wang, Z., Ingram, P., Li, Q., Witte, R. S., & , . (2014, 2012). Optimizing frequency and pulse shape for ultrasound current source density imaging. In 2011 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2138-2141.
- Wang, X., Xin, H., Bauer, D. R., & Witte, R. S. (2014, 2013). Computational Study of Thermoacoustic Imaging for Breast Cancer Detection Using a Realistic Breast Model. In 2013 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI), 2040-2041.
- Witte, R. S., Hall, T., Olafsson, R., O'Donnell, M., & , . (2014, 2007). Inexpensive acoustoelectric hydrophone for measuring high intensity ultrasound fields. In 2007 IEEE ULTRASONICS SYMPOSIUM PROCEEDINGS, VOLS 1-6, 737-740.
- Witte, R. S., Kim, K., Martin, B. J., O'Donnell, M., & , . (2014, 2006). Effect of fatigue on muscle elasticity in the human forearm using ultrasound strain imaging. In 2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-15, 6029-6032.
- Bauer, D. R., Olafsson, R., Montilla, L. G., Witte, R. S., Oraevsky, A., & Wang, L. (2013, 2010). In vivo multi-modality photoacoustic and pulse echo tracking of prostate tumor growth using a window chamber. In PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2010, 7564.
Poster Presentations
- Preston, C., Kasoff, W., & Witte, R. S. (2018, April). Non-invasively mapping deep brain stimulation currents in 4D using acoustoelectric imaging. Minnesota Neuromodulation Symposium. Minneapolis, MN.
- Ingram, P., Bera, T., Burton, A., Hill, D. F., Wilhite, C. A., Witte, R. S., & Cowen, S. L. (2017, November). Acoustoelectric brain imaging: preliminary results in anesthetized rats. UA COM Founder's Day Junior Investigator Poster Forum.
- Martinez, J. A., Chalasani, P., Witte, R. S., Kwoh, C. K., Hadden, A., & Taljanovic, M. (2016, April). Imaging Biomarkers of Aromatase-Inhibitor Induced Joint Pain. University of Arizona, Cancer Center Retreat. Banner University Medical Center, Tucson, AZ.
- Schmitz, H., Witte, R. S., Gao, L., Latt, D. L., Ingram, C. P., Taljanovic, M., Klewer, J., Szivek, J. A., Klewer, J., Szivek, J. A., Ingram, C. P., Taljanovic, M., Gao, L., Latt, D. L., Schmitz, H., & Witte, R. S. (2016, January). Ultrasound Elasticity Imaging of the Posterior Tibial Tendon using FOCUS Simulation Software. 27th Annual Undergraduate Biology Research Program Conference. Tucson, AZ.
- Witte, R. S., Qin, Y., Ingram, P., Burton, A., Tseng, H., Hill, D. F., Wilhite, C. A., Falk, T., Xu, Z., O'Donell, M., & Cowen, S. L. (2016, Fall). Acoustoelectric Brain Imaging of Deep Dipole Sources in a Human Head Phantom. 3rd Annual BRAIN Initiative® Investigators Meeting.
- Ingram, P., Bera, T., Burton, A., Hill, D. F., Wilhite, C. A., Witte, R. S., & Cowen, S. L. (2017, November). Acoustoelectric brain imaging: preliminary results in anesthetized rats. UA COM Founder's Day Junior Investigator Poster Forum.
- Martinez, J. A., Chalasani, P., Witte, R. S., Kwoh, C. K., Hadden, A., & Taljanovic, M. (2016, April). Imaging Biomarkers of Aromatase-Inhibitor Induced Joint Pain. University of Arizona, Cancer Center Retreat. Banner University Medical Center, Tucson, AZ.
- Preston, C., Kasoff, W., & Witte, R. S. (2018, April). Non-invasively mapping deep brain stimulation currents in 4D using acoustoelectric imaging. Minnesota Neuromodulation Symposium. Minneapolis, MN.
- Schmitz, H., Witte, R. S., Gao, L., Latt, D. L., Ingram, C. P., Taljanovic, M., Klewer, J., Szivek, J. A., Klewer, J., Szivek, J. A., Ingram, C. P., Taljanovic, M., Gao, L., Latt, D. L., Schmitz, H., & Witte, R. S. (2016, January). Ultrasound Elasticity Imaging of the Posterior Tibial Tendon using FOCUS Simulation Software. 27th Annual Undergraduate Biology Research Program Conference. Tucson, AZ.
- Witte, R. S., Qin, Y., Ingram, P., Burton, A., Tseng, H., Hill, D. F., Wilhite, C. A., Falk, T., Xu, Z., O'Donell, M., & Cowen, S. L. (2016, Fall). Acoustoelectric Brain Imaging of Deep Dipole Sources in a Human Head Phantom. 3rd Annual BRAIN Initiative® Investigators Meeting.
Presentations
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Lorentz force impedance tomography in 2D: Theory and Experiments. Quantitative Biology Colloquium. U of A.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Rotational Magneto-Acousto-Electric Tomography: Theory and Experiments.. 100 years of the Radon transform. Johannes Keppler University, Linz, Austria.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Rotational Magneto-Acousto-Electric Tomography: Theory and Experiments.. Inverse Problems Seminar. University College London..
- Witte, R. S., Ingram, P., & Kunyansky, L. (2017, January). Lorentz force impedance tomography in 2D: Theory and Experiments. Inverse Problems Seminar.. Texas A&M University.
- Latt, D. L., Gao, L., Taljanovic, M., Szivek, J. A., Guerra, J. D., Klewer, J. A., & Witte, R. S. (2016, March). In Vivo Ultrasound Elasticity Imaging Differentiates Healthy From Diseased Tendons. Orthopaedic Research Society 2016 Annual Meeting. Orlando, Florida.
- Taljanovic, M., Latt, D. L., Gao, L., & Witte, R. S. (2016, March). In Vivo Ultrasound Tension Elastography Differentiates Healthy From Diseased Posterior Tibialis tendon. 39th Annual Meeting of the Society of Skeletal Radiology (SSR). New Orleans, LA: Society of Skeletal Radiology.
- Witte, R. S., Witte, R. S., Latt, D. L., Gao, L., Klewer, J. A., Klewer, J. A., Guerra, J. D., Guerra, J. D., Taljanovic, M., Szivek, J. A., Szivek, J. A., Szivek, J. A., Guerra, J. D., Taljanovic, M., Taljanovic, M., Klewer, J. A., Gao, L., Gao, L., Latt, D. L., , Latt, D. L., et al. (2016, March). In Vivo Ultrasound Elasticity Imaging Differentiates Healthy From Diseased Tendons. ORS 2016 Annual Meeting. Orlando, Florida.
- Latt, D. L., Gao, L., Taljanovic, M., Szivek, J. A., Guerra, J. D., Klewer, J. A., & Witte, R. S. (2016, March). In Vivo Ultrasound Elasticity Imaging Differentiates Healthy From Diseased Tendons. Orthopaedic Research Society 2016 Annual Meeting. Orlando, Florida.
- Taljanovic, M., Latt, D. L., Gao, L., & Witte, R. S. (2016, March). In Vivo Ultrasound Tension Elastography Differentiates Healthy From Diseased Posterior Tibialis tendon. 39th Annual Meeting of the Society of Skeletal Radiology (SSR). New Orleans, LA: Society of Skeletal Radiology.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Lorentz force impedance tomography in 2D: Theory and Experiments. Quantitative Biology Colloquium. U of A.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Rotational Magneto-Acousto-Electric Tomography: Theory and Experiments.. 100 years of the Radon transform. Johannes Keppler University, Linz, Austria.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Rotational Magneto-Acousto-Electric Tomography: Theory and Experiments.. Inverse Problems Seminar. University College London..
- Witte, R. S., Ingram, P., & Kunyansky, L. (2017, January). Lorentz force impedance tomography in 2D: Theory and Experiments. Inverse Problems Seminar.. Texas A&M University.
- Witte, R. S., Witte, R. S., Latt, D. L., Gao, L., Klewer, J. A., Klewer, J. A., Guerra, J. D., Guerra, J. D., Taljanovic, M., Szivek, J. A., Szivek, J. A., Szivek, J. A., Guerra, J. D., Taljanovic, M., Taljanovic, M., Klewer, J. A., Gao, L., Gao, L., Latt, D. L., , Latt, D. L., et al. (2016, March). In Vivo Ultrasound Elasticity Imaging Differentiates Healthy From Diseased Tendons. ORS 2016 Annual Meeting. Orlando, Florida.
Others
- Martinez, J. A., Martinez, J. A., Chalasani, P., Chalasani, P., Witte, R. S., Witte, R. S., Kwoh, C. K., Kwoh, C. K., Hadden, A., Hadden, A., Taljanovic, M., & Taljanovic, M. (2016, April). Imaging Biomarkers of Aromatase-Inhibitor Induced Joint Pain. University of Arizona, Cancer Center Retreat.
- Martinez, J. A., Martinez, J. A., Chalasani, P., Chalasani, P., Witte, R. S., Witte, R. S., Kwoh, C. K., Kwoh, C. K., Hadden, A., Hadden, A., Taljanovic, M., & Taljanovic, M. (2016, April). Imaging Biomarkers of Aromatase-Inhibitor Induced Joint Pain. University of Arizona, Cancer Center Retreat.
- Juneman, E., Lancaster, J., Witte, R., Bahl, J., & Goldman, S. (2012, AUG). Electrical Coupling of a Biological Active Cardiomyocyte Patch. JOURNAL OF CARDIAC FAILURE.
Awards
- Best Prototyping Award
- Mentored Senior Capstone Design Team (2017 - 2018), Fall 2017