utzinger@email.arizona.edu

520.975.0522

Bioscience Research Labs 166

Urs Utzinger's website

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Urs Utzinger

Associate Department Head for Biomedical Engineering Undergraduate Affairs

Associate Professor of Biomedical Engineering

Associate Professor of Obstetrics and Gynecology

Associate Professor of Electrical and Computer Engineering

Associate Professor of Optical Sciences

Associate Professor, BIO5 Institute

I received an engineering degree (Dipl. Ing. ETH, 1989, mechanical engineering) and a Ph.D. (Dr. sc. techn. ETH, 1995, biomedical engineering) from the Swiss Federal Institute of Technology in Zürich Switzerland. As post-doctoral fellow I joined the laboaroty of Rebecca Richards-Kortum (Optical Spectroscopy Laboratory) at The University of Texas, Austin. In 2001, I became faculty at the University of Arizona where I am currently an Associate Professor in Biomedical Engineering. I am also holding appointments in Obstetrics and Gynecology, Optical Sciences, Electrical and Computer Engineering, and the BIO5 Institute.

From 2012 until end of 2014, I served as interim Department Head in Biomedical Engineering when our program grew from 134 to 200 undergraduate students and the first two classes graduated from the program. I currently serve as associate chair for undergraduate affairs.

I develop clinical imaging instrumentation to evaluate gynecological and gastrointestinal cancer. Using microscopy techniques I also study the extra cellular matrix and angiogenesis.

In 2016 I developed the Sophomore Design course for BME undergraduate students where they experience hands-on training on electro mechanical systems. Currenlty I develop a medical devive design course for the Junior year.

My most influential work is listed on Google Scholar.

Degrees

Ph.D. Biomedical Engineering
- Swiss Federal Institute of Technology, Zürich, Switzerland
- Selective Coronary Excimer Laser Angioplasy
M.S. Mechanical Engineering
- Swiss Federal Institute of Technology, Zürich, Switzerland

Work Experience

University of Arizona, Tucson, Arizona (2012 - 2014)
University of Arizona, Tucson, Arizona (2007 - Ongoing)
University of Arizona, Tucson, Arizona (2001 - 2007)
University of Texas, Austin, Texas (1998 - 2001)
University of Texas, Austin, Texas (1995 - 1998)
ETH (1995 - 1995)

Interests

Teaching

Instrumentation,Biomedical Optics,Signal and Data Analysis,Mechatronics & RoboticsDevice Design

Research

Microscopy,Optical SpectroscopySignal and Data Analysis

Courses

Intermediate Engr. Design

BME 210 (Spring 2019)
BME 210 (Spring 2018)
BME 210 (Spring 2017)

Meas&Data Anls Bio Eng

BME 417 (Spring 2019)
BME 417 (Spring 2018)
BME 417 (Spring 2017)
BME 517 (Spring 2019)
BME 517 (Spring 2018)
BME 517 (Spring 2017)
ECE 417 (Spring 2019)
ECE 417 (Spring 2018)
ECE 417 (Spring 2017)
ECE 517 (Spring 2019)
ECE 517 (Spring 2018)
ECE 517 (Spring 2017)

Directed Research

PSIO 492 (Fall 2016)

Clinical Rotation

BME 497G (Fall 2018)
BME 497G (Fall 2017)
BME 497G (Fall 2016)

Independent Study

BME 499 (Fall 2016)

Research

ECE 900 (Fall 2018)

Dissertation

ECE 920 (Spring 2019)

Selected Publications

Journals/Publications

Behkam, R., Kollech, H. G., Jana, A., Hill, A., Danford, F., Howerton, S., Ram, S., RodrÃguez, J. J., Utzinger, U., & Girkin, C. A. (2019). Racioethnic Differences in the Biomechanical Response of the Lamina Cribrosa. Acta biomaterialia.
Black, J. F., & Barton, J. K. (2017). Ultraminiature optical design for multispectral fluorescence imaging endoscopes. Journal of Biomedical Optics, 22(3), 036013-22-10. doi:http://dx.doi.org/10.1117/1.JBO.22.3.036013
Keenan, M., Tate, T. H., Kieu, K., Black, J. F., Utzinger, U., & Barton, J. K. (2017). Design and characterization of a combined OCT and wide field imaging falloposcope for ovarian cancer detection. Biomedical Optics Express, 8(1), 124--136.
Pacheco, S., Wang, C., Chawla, M. K., Nguyen, M., Baggett, B. K., Utzinger, U., Barnes, C. A., & Liang, R. (2017). High resolution, high speed, long working distance, large field of view confocal fluorescence microscope. Scientific Reports, 7(1), 13349.
Dean, Z. S., Elias, P., Jamilpour, N., Utzinger, U., & Wong, P. K. (2016). Probing 3D Collective Cancer Invasion Using Double-Stranded Locked Nucleic Acid Biosensors. Analytical Chemistry, 88(17), 8902--8907.
Tate, T. H., Baggett, B., Rice, P. F., Koevary, J. W., Orsinger, G. V., Nymeyer, A. C., Welge, W. A., Saboda, K., Roe, D. J., Hatch, K. D., & others, . (2016). Multispectral fluorescence imaging of human ovarian and fallopian tube tissue for early-stage cancer detection. Journal of biomedical optics, 21(5), 056005--056005.
Vande Geest, J. P., Haskett, D. G., McIntyre, J. O., Maestas, D., Howerton, S., Mcgrath, D. V., Smith, T., Utzinger, U., Ardilia, C., Doetschman, T. C., Ardilia, C., Doetschman, T. C., Smith, T., Utzinger, U., Howerton, S., McGgrath, D. V., McIntyre, J. O., Maestas, D., Vande Geest, J. P., & Haskett, D. G. (2016). 2-Photon characterization of optical proteolytic beacons for imaging changes in MMP activity in a mouse model of aneurysm. Microscopy and Microanalysis, 22, 349-360. doi:http://dx.doi.org/10.1017/S1431927616000088
Bal, U., Engin, M., & Utzinger, U. (2015). A multiresolution approach for enhancement and denoising of microscopy images. SIGNAL IMAGE AND VIDEO PROCESSING, 9(4), 787-799.
Carbary-Ganz, J. L., Welge, W. A., Barton, J. K., & Utzinger, U. (2015). In vivo molecular imaging of colorectal cancer using quantum dots targeted to vascular endothelial growth factor receptor 2 and optical coherence tomography/laser-induced fluorescence dual-modality imaging. Journal of Biomedical Optics, 20, 096015.
Utzinger, U., Baggett, B., Weiss, J., Hoying, J., & Edgar, L. (2015). Large-scale time series microscopy of neovessel growth during angiogenesis. Angiogenesis, 1-14.
Carbary-Ganz, J. L., Barton, J. K., & Utzinger, U. (2014). Quantum dots targeted to vascular endothelial growth factor receptor 2 as a contrast agent for the detection of colorectal cancer. Journal of biomedical optics, 19(8), 086003.
Edgar, L. T., Hoying, J. B., Utzinger, U., Underwood, C. J., Krishnan, L., Baggett, B. K., Maas, S. A., Guilkey, J. E., & Weiss, J. A. (2014). Mechanical interaction of angiogenic microvessels with the extracellular matrix. Journal of biomechanical engineering, 136(2), 021001.
Geest, J. P., Tong, J., Danford, F., Ayyalasomayajula, A., & Utzinger, U. (2014). Quantification of the pressure dependent anterior microstructure of the lamina cribrosa using multiphoton microscopy. Investigative Ophthalmology \& Visual Science, 55, 4248--4248.
Hoying, J. B., Utzinger, U., & Weiss, J. A. (2014). Formation of microvascular networks: role of stromal interactions directing angiogenic growth. Microcirculation (New York, N.Y. : 1994), 21(4), 278-89.
Watson, J. M., Marion, S. L., Rice, P. F., Bentley, D. L., Besselsen, D. G., Utzinger, U., Hoyer, P. B., & Barton, J. K. (2014). In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis. Cancer Biology and Therapy, 15(1), 42-60.

Proceedings Publications

Keenan, M., Tate, T. H., Black, J. F., Utzinger, U., & Barton, J. K. (2018, January). Performance of combined OCT/MFI microendoscope for ovarian cancer detection. In SPIE Photonics West; Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 9691, 96910D.
Keenan, M., Howard, C., Tate, T., McGuiness, I., Sauer-Budge, A., Black, J., Utzinger, U., & Barton, J. K. (2016, March). Design of an everting balloon to deploy a microendoscope to the fallopian tubes. In Proc. SPIE, 9689, 968944-968944-6.
Wang, C., Pacheco, S., Baggett, B., Chawla, M., Gray, D., Utzinger, U., Barnes, C., & Liang, R. (2016). Whole brain imaging with a scalable microscope. In Clinical and Translational Biophotonics.
Black, J. F., Tate, T., Keenan, M., Swan, E., Utzinger, U., & Barton, J. (2015, Spring). A six-color four-laser mobile platform for multi-spectral fluorescence imaging endoscopy. In SPIE BiOS, 93040T--93040T.
Swan, E., Tate, T., Keenan, M., Black, J. F., Utzinger, U., & Barton, J. (2015, March). Stray light mitigation in a novel endoscope for fallopian tubes. In SPIE BiOS, 93041O--93041O.
Tate, T., Baggett, B., Rice, P., Watson, J., Orsinger, G., Nymeyer, A. C., Welge, W. A., Keenan, M., Saboda, K., Roe, D. J., & others, . (2015, Spring). Multispectral fluorescence imaging of human ovarian and Fallopian tube tissue for early stage cancer detection. In SPIE BiOS, 93130L--93130L.
Tate, T., Keenan, M., Swan, E., Black, J., Utzinger, U., Barton, J., Figueiro, M., Lerner, S., Muschaweck, J., & Rogers, J. (2014, December). Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer. In INTERNATIONAL OPTICAL DESIGN CONFERENCE 2014, 9293.
George, R., Krishnamurthy, R., Lovisa, B., Krikpatrick, N. D., & Utzinger, U. (2006, January). Clinical device for early detection of ovarian cancer using optical spectroscopy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6091, xiii.

Poster Presentations

Ram, S., Howerton, S. J., Danford, F. L., Utzinger, U., Rodriguez, J. J., & Vande Geest, J. (2016, May 1-5). Racioethnic Differences in Biomechanical Environment of the Lamina Cribrosa. ARVO 2016 Annual Meeting. Seattle, WA: Assn. for Research in Vision and Ophthalmology.

Presentations

Keenan, M., Tate, T., Swan, E. J., Black, J. F., Utzinger, U., & Barton, J. K. (2015, Spring). Dual-modal optical imaging microendoscope for ovarian cancer detection. BIOS Photonics West. San Francisco.
Utzinger, U. (2015, September). Imaging Tissue with UV light. Biomedical Engineering Seminar. Texas A&M University, College Station: http://engineering.tamu.edu/biomedical/seminar.
Keenan, M., Tate, T., Swan, E., Black, J., Utzinger, U., & Barton, J. (2014, January). Optical Imaging Falloposcope for Minimally Invasive Ovarian Cancer Detection. Journal of Minimally Invasive Gynecology.
Keenan, M., Tate, T., Swan, E., Black, J., Utzinger, U., & Barton, J. K. (2014, October). Optical Coherence Tomography and Multispectral Fluorescence Imaging Falloposcope. Frontiers in OpticsOptical Society of America.
Utzinger, U. (2014, June). Imaging tissue with UV light, is it worth it?. BC Cancer Research Seminar Series. Vancouver, CA: BC Cancer Agency.