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Medical Research Building, Room 310
Samantha Harris
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Associate Professor of Cellular and Molecular Medicine
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Associate Professor for the BIO5 Institute
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Associate Professor of Physiological Sciences - GIDP
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Co-Chair of ABBS Program
Courses
Honors Independent Study
MCB 199H (Spring 2021)
MCB 399H (Spring 2022)
MCB 399H (Spring 2021)
MCB 399H (Fall 2020)
MCB 399H (Spring 2016)
MCB 499H (Fall 2021)
PSIO 399H (Spring 2019)
Independent Study
ECOL 299 (Spring 2016)
MCB 399 (Spring 2016)
MCB 499 (Spring 2023)
PSIO 399 (Spring 2019)
Directed Rsrch
MCB 392 (Spring 2023)
MCB 392 (Spring 2017)
MCB 392 (Fall 2016)
MCB 492 (Fall 2023)
Directed Research
BIOC 392 (Spring 2018)
BIOC 392 (Spring 2017)
BIOC 492 (Fall 2017)
MCB 792 (Spring 2022)
MCB 792 (Fall 2021)
MCB 792 (Fall 2020)
PSIO 492 (Fall 2019)
Cardio Muscle Bio & Disease
BME 484 (Spring 2024)
BME 484 (Spring 2023)
BME 484 (Spring 2022)
BME 484 (Spring 2021)
BME 484 (Spring 2020)
BME 484 (Spring 2017)
BME 584 (Spring 2024)
BME 584 (Spring 2023)
BME 584 (Spring 2022)
BME 584 (Spring 2021)
BME 584 (Spring 2020)
BME 584 (Spring 2017)
CMM 484 (Spring 2024)
CMM 484 (Spring 2020)
CMM 584 (Spring 2024)
CMM 584 (Spring 2022)
CMM 584 (Spring 2021)
CMM 584 (Spring 2020)
CMM 584 (Spring 2019)
CMM 584 (Spring 2017)
MCB 484 (Spring 2023)
MCB 484 (Spring 2021)
MCB 484 (Spring 2020)
MCB 484 (Spring 2019)
MCB 584 (Spring 2021)
PSIO 484 (Spring 2024)
PSIO 484 (Spring 2023)
PSIO 484 (Spring 2022)
PSIO 484 (Spring 2021)
PSIO 484 (Spring 2020)
PSIO 484 (Spring 2019)
PSIO 484 (Spring 2018)
PSIO 484 (Spring 2017)
PSIO 584 (Spring 2024)
PSIO 584 (Spring 2023)
PSIO 584 (Spring 2022)
PSIO 584 (Spring 2021)
PSIO 584 (Spring 2019)
PSIO 584 (Spring 2018)
Senior Capstone
BIOC 498 (Summer I 2019)
BIOC 498 (Spring 2019)
BIOC 498 (Fall 2018)
BIOC 498 (Spring 2016)
MCB 498 (Spring 2024)
MCB 498 (Fall 2023)
Honors Thesis
BIOC 498H (Spring 2023)
BIOC 498H (Fall 2022)
MCB 498H (Spring 2023)
MCB 498H (Fall 2022)
Physiology/Biomed Engr
BME 511 (Spring 2024)
BME 511 (Spring 2023)
PSIO 511 (Spring 2024)
PSIO 511 (Spring 2023)
Prin of Cell Biology
CMM 577 (Fall 2019)
CMM 577 (Fall 2018)
CMM 577 (Fall 2017)
CMM 577 (Fall 2016)
MCB 577 (Fall 2019)
MCB 577 (Fall 2018)
MCB 577 (Fall 2017)
MCB 577 (Fall 2016)
Journal Club
CMM 595A (Fall 2022)
CMM 595A (Spring 2022)
CMM 595A (Fall 2021)
CMM 595A (Spring 2021)
CMM 595A (Fall 2020)
CMM 595A (Spring 2020)
CMM 595A (Fall 2019)
CMM 595A (Fall 2018)
CMM 595A (Spring 2018)
CMM 595A (Fall 2017)
CMM 595A (Spring 2017)
CMM 595A (Fall 2016)
Human Physiology
PSIO 603A (Spring 2024)
Crnt Tops in Translational Med
CMM 604 (Spring 2016)
ABBS Student Forum
GRAD 696C (Spring 2022)
GRAD 696C (Fall 2021)
GRAD 696C (Spring 2021)
GRAD 696C (Fall 2020)
GRAD 696C (Spring 2020)
GRAD 696C (Fall 2019)
GRAD 696C (Spring 2019)
GRAD 696C (Fall 2018)
GRAD 696C (Spring 2018)
GRAD 696C (Fall 2017)
GRAD 696C (Spring 2017)
Rsrch Meth Psio Sci
PS 700 (Fall 2019)
Introduction to Research
MCB 795A (Fall 2019)
MCB 795A (Fall 2017)
Research
CMM 900 (Spring 2022)
CMM 900 (Fall 2021)
CMM 900 (Fall 2020)
CMM 900 (Fall 2017)
CMM 900 (Spring 2017)
CMM 900 (Fall 2016)
CMM 900 (Spring 2016)
Thesis
CMM 910 (Fall 2017)
Dissertation
BME 920 (Fall 2024)
BME 920 (Spring 2024)
BME 920 (Fall 2023)
CMM 920 (Spring 2024)
CMM 920 (Fall 2023)
CMM 920 (Spring 2023)
CMM 920 (Fall 2022)
CMM 920 (Spring 2022)
Selected Publications
Journals/Publications
- Hessel, A. L., Engels, N. M., Kuehn, M., Nissen, D., Sadler, R. L., Ma, W., Irving, T. C., Linke, W. A., & Harris, S. P. (2023). Myosin-binding protein C forms C-links and stabilizes OFF states of myosin. bioRxiv : the preprint server for biology.
- Lo, S. T., Li, R. H., Georges, C. J., Nguyen, N., Chen, C. K., Stuhlmann, C., Oldach, M. S., Rivas, V. N., Fousse, S., Harris, S. P., & Stern, J. A. (2023). Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet-dependent thrombin generation in cats. Journal of veterinary internal medicine, 37(4), 1390-1400.
- Rivas, V. N., Kaplan, J. L., Kennedy, S. A., Fitzgerald, S., Crofton, A. E., Farrell, A., Grubb, L., Jauregui, C. E., Grigorean, G., Choi, E., Harris, S. P., & Stern, J. A. (2023). Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study. Animals : an open access journal from MDPI, 13(20).
- Sharpe, A. N., Oldach, M. S., Kaplan, J. L., Rivas, V., Kovacs, S. L., Hwee, D. T., Morgan, B. P., Malik, F. I., Harris, S. P., & Stern, J. A. (2023). Pharmacokinetics of a single dose of Aficamten (CK-274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model. Journal of veterinary pharmacology and therapeutics, 46(1), 52-61.
- Sharpe, A. N., Oldach, M. S., Rivas, V. N., Kaplan, J. L., Walker, A. L., Kovacs, S. L., Hwee, D. T., Cremin, P., Morgan, B. P., Malik, F. I., Harris, S. P., & Stern, J. A. (2023). Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy. Scientific reports, 13(1), 32.
- Stern, J. A., Rivas, V. N., Kaplan, J. L., Ueda, Y., Oldach, M. S., Ontiveros, E. S., Kooiker, K. B., van Dijk, S. J., & Harris, S. P. (2023). Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C. Scientific reports, 13(1), 10319.
- Papadaki, M., Kampaengsri, T., Barrick, S. K., Campbell, S. G., von Lewinski, D., Rainer, P. P., Harris, S. P., Greenberg, M. J., & Kirk, J. A. (2022). Myofilament glycation in diabetes reduces contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains. Journal of molecular and cellular cardiology, 162, 1-9.
- Risi, C. M., Villanueva, E., Belknap, B., Sadler, R. L., Harris, S. P., White, H. D., & Galkin, V. E. (2022). Cryo-Electron Microscopy Reveals Cardiac Myosin Binding Protein-C M-Domain Interactions with the Thin Filament. Journal of molecular biology, 434(24), 167879.
- Walker, A. L., Ueda, Y., Crofton, A. E., Harris, S. P., & Stern, J. A. (2022). Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy. Scientific reports, 12(1), 1963.
- Harris, S. P. (2021). Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle. The Journal of general physiology, 153(3).
- Harris, S., Langlais, P. R., Granger, K., Napierski, N., Touma, K., Moran, H., & Strom, J. (2020). A novel “cut and paste” method for in situ replacement of cMyBP-C reveals a new role for cMyBP-C in the regulation of contractile oscillations. Circulation Research.
- Harris, S., Touma, K., Strom, J., Moran, H. R., Langlais, P. R., Granger, K., & Napierski, N. C. (2020). A novel “cut and paste” method for in situ replacement of cMyBP-C reveals a new role for cMyBP-C in the regulation of contractile oscillations. Circulation Research.
- Risi, C. M., Patra, M., Belknap, B., Harris, S. P., White, H. D., & Galkin, V. E. (2021). Interaction of the C2 Ig-like Domain of Cardiac Myosin Binding Protein-C with F-actin. Journal of molecular biology, 433(19), 167178.
- Harris, S., Langlais, P. R., Granger, K., Napierski, N., Touma, K., Moran, H., & Strom, J. (2020). A novel “cut and paste” method for in situ replacement of cMyBP-C reveals a new role for cMyBP-C in the regulation of contractile oscillations. Circulation Research. doi:10.1161/CIRCRESAHA.119.315760
- Napierski, N. C., Granger, K., Langlais, P. R., Moran, H. R., Strom, J., Touma, K., & Harris, S. P. (2020). A Novel "Cut and Paste" Method for In Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation of Contractile Oscillations. Circulation research, 126(6), 737-749.
Poster Presentations
- Harris, S. (2018, Sept/Fall). Acute loss of cMyBP-C N’-terminal domains induces spontaneous oscillatory contractions (SPOC) in permeabilized myocytes from Spy-C mice. European Muscle Conference Annual Meeting, Budapest, Hungary.
Presentations
- Harris, S. (2019, April). Regulation of cardiac contraction by cMyBP-C: Introducing a novel cut and paste approach for studying sarcomeric proteins. Invited seminar speaker at Cytokinetics, South San Francisco, CA (April, 2019)Cytokinetics, Inc..
- Harris, S. (2019, April/Spring). A cut and paste approach for studyingcardiac myosin binding protein-C. Invited seminar at Cincinnati Children's Hospital, Cincinnati, OH. Cincinnati, OH: Cincinnati Children's Hospital.
- Harris, S. (2019, April/Spring). A cut and paste approach to studyingcardiac myosin binding protein-C. Invited seminar at Tufts University. Boston, MA: Tufts University.
- Harris, S. (2019, April/Spring). What's the Catch? Lessons Marion Taught Me about Mussels, Muscles and Myosin Binding Protein-C. Award recipient and invited lecturer for Marion J. Siegman Lectureship, American Physiological Society, Experimental Biology, Orlando, FL. Orlando, FL: American Physiological Society.
- Harris, S. (2019, August). Stop making waves: A new role for cardiac myosin binding protein-C in damping contractile oscillations. Invited speaker at International Society of Biomechanics/American Society of Biomechanics, Calgary, Alberta, Canada (August, 2019).. Calgary, Canada: International Society of Biomechanics/American Society of Biomechanics.
- Harris, S. (2019, July). Stop making waves: A new role for cardiac myosin binding protein-C in damping contractile oscillations. Invited speaker at American Heart Association, Basic Council on Cardiovascular Sciences (July, 2019). Boston, MA: American Heart Association.
- Harris, S. (2019, March/Winter). Acute loss of cMyBP-C inducesauto-oscillations in cardiac sarcomeres: Implications for reverse EC coupling?. Invited symposium speaker for the annual meeting of the Biophysical Society, Baltimore, MD. Baltimore, MD: Biophysical Society.
- Harris, S. (2019, November). Making waves: A new role for Cardiac myosin binding protein-C (cMyBP-C) in damping contractile oscillations. Invited seminar at the Pennsylvania Muscle Institute. Philadelphia, PA: University of Pennsylvania.
- Harris, S. (2019, November). Making waves: A novel role for cMyBP-C in damping contractile oscillations. Invited speaker at the annual meeting of Scientific Sessions. Philadelphia, PA: American Heart Association.
- Harris, S. (2019, November). Stop making waves: A new role for cardiac myosin binding protein-C in damping contractile oscillations. Invited seminar at Texas A&M University. College Station, TX: Texas A&M University.
- Harris, S. (2019, October). Stop making waves: A new role for cardiac myosin binding protein-C in damping contractile oscillations. Invited seminar at Fralin Biomedical Research Institute. Roanoke, VA: Virginia Tech Carilion School of Medicine.
- Harris, S. (2019, September). Stop making waves: A new role for cardiac myosin binding protein-C in damping contractile oscillations. Faculty seminar in BioMedical Engineering. Tucson, AZ: Biomedical Engineering, U Arizona.
- Harris, S. (2019, September). Stop making waves: A new role for cardiac myosin binding protein-C in damping contractile oscillations. Invited seminar speaker at Eastern Virginia Medical School. Norfolk, VA: Eastern Virginia Medical School.
- Harris, S. (2018, April/Spring). Regulation of cardiac contraction by cMyBP-C. Invited seminar at Novartis. Boston, MA: Novartis.
- Harris, S. (2018, April/Spring). Regulation of cardiac contraction by cardiac myosin binding protein-C (cMyBP-C). Invited departmental seminar at Washington University School of Medicine, Dept of Biochemistry and Molecular Biophysics. St. Louis, MO: Washington University School of Medicine, Dept of Biochemistry and Molecular Biophysics.
Awards
- Annual Marion J Siegman Lectureship Award of American Physiological Society
- American Physiological Society, Spring 2019
- Nomination for regular membership on the CCHF (Cardiac contractility, hypertrophy, and failure) NIH CSR study section.
- NIH Center for Scientific Review, Fall 2015