BME Seminar: Alexander Day
Monday, November 29th, 2021, 12:00 p.m.
Alexander Day
Ph.D. Candidate, University of Arizona
Jeong-Yeol Yoon Lab
"Reimagining Existing Technologies for Faster Time-to-Detection of Biomarkers of Interest"
Keating 103
Live Zoom | Passcode: BearDown
(Instructor permission required for enrolled students to attend via Zoom)
Hosts: Dr. Beth Hutchinson and Dr. Russ Witte
ABSTRACT:
Many of the gold standard technologies used today in the clinical environment benefit from high sensitivity/specificity and familiarity in the world however, they may also be hampered from providing adequate care due to long time-to-results, thus not making them fit for rapid in-clinic diagnostic tools. Gold standard methods (such as flow cytometry for cell subpopulation analysis and RT-PCR for pathogen/biomarker detection) could be far more useful for patients if improved to allow for rapid time-to-detection. To that end, this presentation will focus on the development of biosensing platforms that lead to more rapid and specific detection of biomarkers of interest. These platforms will include the use of fluorescent particles combined with paper microfluidics/smartphone microscopy for rapid natural killer cell subpopulation analysis and the evolution of an emulsion-based nucleic acid amplification platform. Such technologies have been proven to be effective at providing users with results in less than 10 minutes, potentially allowing for in-clinic use rather than having to be sent off to separate laboratories.
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