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Arizona Health Science Center 1343
Srinivasan Vedantham
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Professor of Medical Imaging
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Director, Office for Project Statistical and Design Support in the Department of Medical Imaging
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Associate Director, Biomedical Imaging Innovation and Clinical Translation in Next-Gen CT
Srinivasan Vedantham, PhD, FAAPM, is a Professor in the Department of Medical Imaging. He joined the University of Arizona after serving as a faculty at the Department of Radiology at the University of Massachusetts Medical School and as an adjunct faculty in Biomedical Engineering at Worcester Polytechnic Institute. He received his PhD in Biomedical Engineering from Worcester Polytechnic Institute, Worcester, MA, and subsequently joined as a faculty at the Department of Radiology at Emory University School of Medicine, Atlanta, GA.
Dr. Vedantham has received numerous honors and awards. He received the Cancer Research Award from the Georgia Cancer Coalition and the Dr. Karen Mudry Award from the Institute of Biomedical Engineering Research (IBER). He contributed to the article that received the Farrington Daniels Award for the best paper in radiation dosimetry in Medical Physics Journal and the article that was selected as Editor’s Choice in Basic Science in the Journal of Neurointerventional Surgery.
Dr. Vedantham is a member of several professional organizations: The American Association of Physicists in Medicine (AAPM), the Institute of Electrical and Electronics Engineers (IEEE), and the International Society for Optics and Photonics (SPIE). He was elected as Fellow by the American Association of Physicists in Medicine (AAPM).
Degrees
- Ph.D. Biomedical Engineering
- Worcester Polytechnic Institute, Worcester, Massachusetts, United States
- Design and characterization of a high-resolution cardiovascular imager
- M.S. Biomedical Engineering
- The University of Akron, Akron, Ohio, United States
- Assessment of Cadmium Zinc Telluride (CZT) for x-ray imaging
- B.E. (Honors) Electrical and Electronics Engineering
- Birla Institute of Technology and Science, Pilani, Rajasthan, India
Work Experience
- Department of Radiology, University of Massachusetts Medical School (2011 - 2017)
- Department of Radiology, University of Massachusetts Medical School (2007 - 2011)
- Department of Radiology, Emory University School of Medicine (2002 - 2007)
- Radiologic Physics Laboratory, University of Massachusetts Medical School (1997 - 2002)
- Biomedical Engineering Department, The University of Akron (1995 - 1997)
- Department of Radiology, University of Miami (1995 - 1995)
- Medical Engineering Division, Siemens Ltd. (1992 - 1994)
- GEC Alsthom LTD (1992 - 1992)
Interests
Teaching
My teaching interests are to provide didactic lectures in Medical Imaging Physics for Residents and Fellows, to provide graduate education on x-ray imaging modalities including radiography, mammography, fluoroscopy, tomosynthesis and computed tomography (CT), and to provide continuing education courses through professional organizations.
Research
My research interests are in the design, development and clinical translation of novel x-ray imaging systems and imaging techniques with particular focus on oncological and interventional imaging. Along with my collaborators and colleagues, I have made contributions to breast cancer imaging including small-field digital mammography for stereotactic core-biopsies, full-field digital mammography and digital breast tomosynthesis. Currently, I am working on developing advanced tomographic techniques and systems for breast imaging and its clinical translation. This design, development and clinical translation oriented research is funded by the National Institutes of Health. I also conduct research in interventional imaging with a focus on developing advanced detector technology.
Courses
Rsrch Meth Biomed Engr
BME 592 (Fall 2021)
BME 592 (Spring 2021)
Advanced Medical Imaging
BME 638 (Spring 2018)
OPTI 638 (Spring 2023)
OPTI 638 (Spring 2021)
OPTI 638 (Spring 2019)
OPTI 638 (Spring 2018)
Research
BME 900 (Spring 2022)
Thesis
BME 910 (Fall 2022)
Dissertation
BME 920 (Fall 2024)
BME 920 (Spring 2024)
BME 920 (Fall 2023)
BME 920 (Spring 2023)
BME 920 (Fall 2022)
BME 920 (Spring 2022)
BME 920 (Fall 2021)
BME 920 (Spring 2021)
Licensure & Certification
- Radiomics, American Association of Physicists in Medicine (2018)
- Diagnostic Medical Physics, American Board of Radiology (2017)
Selected Publications
Chapters
- Karellas, A., Avery, R., Covington, M., Eisenbrey, J., Jokerst, C., Saranathan, M., Sharma, P., & Vedantham, S. (2022). Physics in Imaging Special Edition Module. In American College of Radiology Continuous Professional Improvement (CPI). American College of Radiology.
- Vedantham, S., Sharma, P., Saranathan, M., Covington, M. F., Eisenbrey, J. R., & Jokerst, C. E. (2022). CPI Physics in Imaging Special Edition Module. In ACR Continuous Professional Improvement. Reston, VA: American College of Radiology. doi:10.54057/cpi.ph2022
- Karellas, A., & Vedantham, S. (2020).
Clinical Mammography Physics
. In Clinical Imaging Physics: Current and Emerging Practice. doi:10.1002/9781118753798.ch7
- Karellas, A., & Vedantham, S. (2020). Clinical Mammography Physics: Emerging Practice. In Clinical Medical Imaging Physics: Current and Emerging Practice (E Samei, DE Pfeiffer, Eds.)(p. 107). John Wiley & Sons.
- Vedantham, S. (2018). Tissue Substitute Materials for Diagnostic X-ray Imaging. In Handbook of X-ray Imaging (Russo P, Ed.)(pp 1107-1132). Boca Raton, FL: Taylor & Francis Group, CRC Press.
- Karellas, A., & Vedantham, S. (2017). The Breast X-ray Imaging Continuum – Mammography, Digital Breast Tomosynthesis and Cone-beam Breast Computed Tomography. In Essentials: Dedicated Cone-beam Breast Computed Tomography (O’Connell AM, Ed.)(pp 9-13). Pittsford, NY: Imaging Science Today, LLC.
- Vedantham, S. (2017). Tissue Substitute Materials for Diagnostic X-ray Imaging. In Handbook of X-ray Imaging. Routledge Handbooks Online. doi:10.1201/9781351228251-56
- Vedantham, S., Karellas, A., & Vijayaraghavan, G. R. (2017). Dedicated Cone-beam Breast Computed Tomography versus. Digital Breast Tomosynthesis. In Essentials: Dedicated Cone-beam Breast Computed Tomography (O’Connell AM, Ed.)(pp 78-93). Pittsford, NY: Imaging Science Today, LLC.
- Karellas, A., & Vedantham, S. (2015). Radiologic image formation: physical principles, technology, and radiation dose considerations. In Diagnostic Imaging of Child Abuse. doi:10.1017/CBO9780511862366.040
- Vijayaraghavan, G. R., Vedantham, S., Khan, A., & Karellas, A. (2015). Molecular Basis of Breast Cancer Imaging. In Precision Molecular Pathology of Breast Cancer. Springer, New York, NY. doi:10.1007/978-1-4939-2886-6_1
- Karellas, A., Vedantham, S., Whitman, G. J., & Haygood, T. M. (2009). Detectors for digital mammography. In Digital mammography: a practical approach. Cambridge University Press. doi:10.1017/CBO9781139049337.002
Journals/Publications
- Fu, Z., Tseng, H. W., & Vedantham, S. (2024). An attenuation field network for dedicated cone beam breast CT with short scan and offset detector geometry. Scientific reports, 14(1), 319.
- Nisbet, A. I., Ahmadian, D., Vedantham, S., & Chiang, J. A. (2024). An unusual artifact observed on screening mammography in a patient with an LVAD. Journal of applied clinical medical physics, e14255.
- Shazeeb, M. S., Moholkar, V., King, R. M., Vedantham, S., Vardar, Z., Kraitem, A., Lindsay, C., Anagnostakou, V., Singh, J., Massari, F., de Macedo Rodrigues, K., Naragum, V., Puri, A. S., Carniato, S., Gounis, M. J., & Kühn, A. L. (2023). Assessment of thrombectomy procedure difficulty by neurointerventionalists based on vessel geometry parameters from carotid artery 3D reconstructions. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 113, 121-125.
- Vedantham, S. (2023). Contrast-enhanced breast computed tomography: can lymph node metastasis be predicted from primary tumor?. European radiology.
- Vedantham, S., Shazeeb, M. S., Chiang, A., & Vijayaraghavan, G. R. (2023). Artificial Intelligence in Breast X-Ray Imaging. Seminars in ultrasound, CT, and MR, 44(1), 2-7.
- Vedantham, S., Tseng, H. W., Fu, Z., & Chow, H. S. (2023). Dedicated Cone-Beam Breast CT: Reproducibility of Volumetric Glandular Fraction with Advanced Image Reconstruction Methods. Tomography (Ann Arbor, Mich.), 9(6), 2039-2051.
- Vijayaraghavan, G. R., Ge, C., Lee, A., Roubil, J. G., Kandil, D. H., Dinh, K. H., & Vedantham, S. (2023). Savi-Scout Radar Localization: Transitioning From the Traditional Wire Localization to Wireless Technology for Surgical Guidance at Lumpectomies. Seminars in ultrasound, CT, and MR, 44(1), 12-17.
- Vijayaraghavan, G. R., Guembou, I. M., & Vedantham, S. (2023). The Current State of Timeliness in the Breast Cancer Diagnosis Journey: Abnormal Screening to Biopsy. Seminars in ultrasound, CT, and MR, 44(1), 56-61.
- Vijayargahavan, G. R., Watkins, J., Tyminski, M., Venkataraman, S., Amornsiripanitch, N., Newburg, A., Ghosh, E., & Vedantham, S. (2023). Audit of Prior Screening Mammograms of Screen-Detected Cancers: Implications for the Delay in Breast Cancer Detection. Seminars in ultrasound, CT, and MR, 44(1), 62-69.
- Bilgin, A., Karellas, A., Vedantham, S., Tseng, H. W., & Fu, Z. (2020). A Multi-Slice Residual Dense Network Assisted Sparse-view Reconstruction for Breast Computed Tomography. Scientific Reports.
- Chen, J. Y., Vedantham, S., & Lexa, F. J. (2022). Burnout and work-work imbalance in radiology- wicked problems on a global scale. A baseline pre-COVID-19 survey of US neuroradiologists compared to international radiologists and adjacent staff. European journal of radiology, 110153.
- Di Maria, S., Vedantham, S., & Vaz, P. (2022). Breast dosimetry in alternative X-ray-based imaging modalities used in current clinical practices. European journal of radiology, 155, 110509.
- Di Maria, S., Vedantham, S., & Vaz, P. (2022). X-ray dosimetry in breast cancer screening: 2D and 3D mammography. European journal of radiology, 151, 110278.
- Roychowdhury, P., Vijayaraghavan, G. R., Roubil, J., Williams, I. M., Siddiqui, E., & Vedantham, S. (2022). Value of BI-RADS 3 Audits. Biomedical journal of scientific & technical research, 41(5), 33086-33092.
- Tseng, H. W., Karellas, A., & Vedantham, S. (2022). Dedicated cone-beam breast CT: Data acquisition strategies based on projection angle-dependent normalized glandular dose coefficients. Medical physics.
Proceedings Publications
- Chow, H., Vedantham, S., Roe, D., Tseng, H., Chiang, J. A., Centuori, S. M., Chalasani, P., Garcia, D. O., Garcia, D. O., Chalasani, P., Centuori, S. M., Chiang, J. A., Tseng, H., Roe, D., Vedantham, S., & Chow, H. (2023). Feasibility of quantitative breast density measurements in obese women with dedicated cone-beam breast CT.. In 2023 Program of the 10th International Breast Density & Cancer Risk Assessment Workshop, a21.
- Fu, Z., Tseng, H., & Vedantham, S. (2023). An Attenuation Field Network reconstruction using short-scan and offset detector data for cone-beam breast CT.. In Medical Physics 50-6, 2023 AAPM Meeting Program..
- Larsen, T. C., Tseng, H., Trinate, R., Fu, Z., Karellas, A., & Vedantham, S. (2023). Joint optimization of X-ray spectrum and scintillator thickness used in the detector for microcalcification detection in dedicated cone-beam breast CT.. In Medical Physics 50-6, 2023 AAPM Meeting Program.
- Reynolds, C., Renshaw, B., Vedantham, S., & Rogers, S. (2023). Utilizing DSC MR perfusion images for evaluation of hemorrhagic transformation after mechanical thrombectomy with Heidelberg grading and comparison to SWI, GRE, and CT.. In Journal of NeuroInterventional Surgery, 15 (Suppl 1), A14-A15.
- Trinate, R., Tseng, H., Larsen, T. C., Fu, Z., & Vedantham, S. (2023). Objective physics-based image quality characterization of a low-noise, high-resolution, dedicated cone-beam breast CT using an offset detector.. In Medical Physics 50-6, 2023 AAPM Annual Meeting Program, Abstract # SU-400-351-3.
- Tseng, H., Fu, Z., & Vedantham, S. (2023). Radiation dose reduction in cone-beam breast CT using shorter X-ray pulse-width with a self-supervised deep learning algorithm.. In Medical Physics 50-6, 2023 AAPM Annual Meeting Program.
- Tseng, H., Fu, Z., Chiang, J. A., Chow, H., & Vedantham, S. (2023). Patient-specific mean glandular dose from a high-resolution dedicated cone-beam breast CT system with offset detector.. In Medical Physics 50-6, 2023 AAPM Meeting Program.
- Vedantham, S., Tseng, H., Fu, Z., & Chow, H. (2023). Reproducibility of volumetric fibroglandular fraction in dedicated cone-beam breast CT.. In 2023 Program of the 10th International Breast Density & Cancer Risk Assessment Workshop, a10.
- Tseng, H., Karellas, A., & Vedantham, S. (2022).
Angular normalized glandular dose coefficient in breast CT: clinical data study
. In 7th International Conference on Image Formation in X-Ray Computed Tomography, 12304, 158-163.
- Shazeeb, M., Moholkar, V., King, R., Kuhn, A., Vedantham, S., Vardar, Z., Kraitem, A., Anagnostakou, V., Singh, J., Massari, F., de Macedo Rodrigues, K., Naragum, V., Puri, A., & Gounis, M. (2021, 06/Summer). Assessment of thrombectomy procedure difficulty by neurointerventionalists based on vessel geometry parameters from carotid artery 3D reconstructions. In 18th Annual Meeting of the Society of NeuroInterventional Surgery (SNIS), 13, A11-A11.
- Tseng, H., Karellas, A., & Vedantham, S. (2021, 07/Summer). Dedicated Cone-Beam Breast CT with Offset-Detector: Estimates of Mean Glandular Dose (MGD) with Heterogeneous Tissue Distribution and Real Breast Shapes from Clinical Datasets. In 63rd Annual Meeting of the American Association of Physicists in Medicine (AAPM), 48.
- Umapathy, L., Guzman Perez-Carillo, G., Winegar, B., Vedantham, S., Altbach, M., & Bilgin, A. (2021, 05/Spring). White matter hyperintensity volumes and cognition: Assessment of a deep learning-based lesion detection and quantification algorithm onADNI. In 2021 Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2021).
- Vedantham, S., Tseng, H., & Karellas, A. (2021, 07/Summer). Image Quality Evaluation of a Compressed-Sensing Algorithm for Image Reconstruction in Dedicated Cone-Beam Breast CT Using Offset-Detector. In 63rd Annual Meeting of the American Association of Physicists in Medicine (AAPM), 48.
- Jaffer, F., Chan, Y., Kumar, S., Parbtani, R., Vedantham, S., & Malo, J. (2020, May). High Risk Findings on Low Dose CT in a Coccidioidomycosis Endemic Area. In American Thoracic Society, Am J Respir Crit Care Med, A5938.
- Malo, J., Vedantham, S., Kumar, S., Jaffer, F., Chan, Y., Rao, S., & Parbtani, R. (2020, May). High Risk Findings on Low Dose CT in a Coccidioidomycosis Endemic Area. In American Thoracic Society (abstract in Am J Crit Care Med), 201, A5938.
Poster Presentations
- Larsen, T. C., Tseng, H., Trinate, R., Fu, Z., & Vedantham, S. (2023, February). Maximizing microcalcification detectability in low dose dedicated cone beam breast CT: Parallel cascades-based theoretical analysis. 11th Annual BME Research Expo. University of Arizona.
- Larsen, T. C., Tseng, H., Trinate, R., Fu, Z., Karellas, A., & Vedantham, S. (2023). Joint optimization of scintillator thickness and x-ray spectrum for microcalcification detection in dedicated cone-beam breast CT.. American Physician Scientists Assocation (APSA) 2023 Joint Meeting. Chicago, IL.
- Trinate, R., Tseng, H., Larsen, T. C., Fu, Z., & Vedantham, S. (2023, February). Quantitative evaluation of image quality for dedicated cone-beam computerized tomography. 11th Annual BME Research Expo. University of Arizona.
- Fu, Z., Tseng, H., Karellas, A., & Vedantham, S. (2022).
A Self-supervised Pseudo-3D Network for Cone-beam Dedicated Breast CT Denoising.
. The University of Arizona Cancer Center’s Annual Scientific Retreat 2022. Tucson, AZ: University of Arizona Cancer Center. - Tseng, H., Fu, Z., Karellas, A., & Vedantham, S. (2022). Radiation dose reduction for the dedicated breast CT using shorter x-ray pulse width and model-based iterative reconstruction algorithm.. The University of Arizona Cancer Center’s Annual Scientific Retreat 2022. Tucson, AZ: University of Arizona Cancer Center.
- Tseng, H., Vedantham, S., & Karellas, A. (2019, Aug 2019). Impact of Uniform and Nonuniform Angular Sampling in Short-Scan Dedicated Breast Computed Tomography. 61st Annual Meeting of the American Association of Physicists in Medicine (AAPM), MEDICAL PHYSICS 46 (6), E428-E428. San Antonio, TX: American Association of Physicists in Medicine (AAPM).
Presentations
- Duhancioglu, G., Gupta, K., Reynolds, C., Vedantham, S., & Arif Tiwari, H. (2023, April). Multiparametric MRI characterization for diagnosing acute cholecystitis.. 2023 American Roentgen Ray Society (ARRS) Annual Meeting.
- Fu, Z., Tseng, H., & Vedantham, S. (2023). An attenuation field network for cone-beam breast CT with a laterally-shifted detector in short scan.. 17th International Meeting on Fully 3D image reconstruction in Radiology and Nuclear medicine.
- Greenhill, M., Rounseville, B., Elcic, L., Trujillo, M., Vedantham, S., & Arif Tiwari, H. (2023, April). Implementation of an abbreviated venous duplex ultrasound protocol for detection of deep vein thrombus in hospitalized COVID-19 (+) patients. Annual Meeting of the American Roentgen Ray Society (ARRS 2023). Honolulu, HI: American Roentgen Ray Society.
- Rogers, S., Renshaw, B., Reynolds, C. A., Frazzitta, A., Bhandari, A., & Vedantham, S. (2023, April). Validating Heildelberg ratings of hemorrhagic transformation after mechanical thrombectomy on MRI with SWI and GRE sequences, with comparison to CT. Annual Meeting of the American Society of Neuroradiology (ASNR 2023). Chicago, IL: American Society of Neuroradiology.
- Rogers, S., Reynolds, C. A., Frazzitta, A., Renshaw, B., Bhandari, A., & Vedantham, S. (2023, April). Contrast-enhanced FLAIR and the relationship to hemorrhagic transformation in patients with large vessel occlusion treated with mechanical thrombectoy. Annual Meeting of the American Society of Neuroradiology 2023 (ASNR 2023). Chicago, IL: American Society of Neuroradiology.
- Vedantham, S. (2023). Advanced breast CT and quantitative breast cancer assessment.. National Cancer Institute, Quantitative Imaging Working Group.
- A, B., Vedantham, S., Rogers, S., Mushtaq, R., & R, W. J. (2022). Imaging Characteristics of Hyperostosis Frontalis Interna.. 54th Annual Meeting of the Western Neuroradiology Society. Indian Wells, CA: Western Neuroradiology Society.
- D, C., J, L., Vedantham, S., Kubal, W. S., & Mushtaq, R. (2022). Temporal enhancement pattern between Cavernous Sinus and Suboccipital Cavernous Sinus: Results from analysis of MRI data.. 54th Annual Meeting of the Western Neuroradiology Society. Indian Wells, CA: Western Neuroradiology Society.
- Di Maria, S., Vedantham, S., & Vaz, P. (2022, October). X-ray dosimetry in breast cancer screening: state-of-the-art and emerging technologies. European Radiation Protection Week (ERPW 2022). Estoril (Lisbon), Portugal.
- Fu, Z., Tseng, H., Karellas, A., & Vedantham, S. (2022). Dedicated Breast CT Image Reconstruction: Self-supervised Denoising from Single Image. 2022 University of Arizona College of Medicine Research Day. Tucson, AZ.
- J, L., D, C., Vedantham, S., Kubal, W. S., & Mushtaq, R. (2022). Quantitative association between CS and SCS enhancement: Results from analysis of CT data. . 54th Annual Meeting of the Western Neuroradiology Society. Indian Wells, CA: Western Neuroradiology Society.
- Tseng, H., Karellas, A., & Vedantham, S. (2022). Angular Normalized Dose Coefficients in Breast CT: Clinical data study.. University of Arizona College of Medicine Research Day. Tucson, AZ.
- Vedantham, S. (2021, 08/Fall). Towards breast cancer screening with dedicated breast computed tomography (CT). University of Arizona Cancer Center Collaborative Grand Rounds. Tucson, AZ: University of Arizona Cancer Center (UACC).
- Vedantham, S. (2021, 09/Fall). Screening for Breast Cancer with Dedicated Breast Computed Tomography. Biomedical Engineering Seminar, Rennselaer Polytechnic InstituteRennselaer Polytechnic Institute.
- Vedantham, S. (2021, 11/Fall). Breast cancer screening with dedicated breast computed tomography: Challenges and Opportunities. Research Seminar, Department of Radiological Sciences, University of California at Irvine (UCI)University of California at Irvine (UCI).
Awards
- Elected Fellow
- American Association of Physicists in Medicine (AAPM), Summer I 2016