BME Seminar: Shella Keilholz
Monday, January 30th, 2023 - 12:00 p.m.
Shella Keilholz
Professor of Biomedical Engineering
Joint Emory University & Georgia Tech
"The Organization of Intrinsic Brain Activity"
Keating 103
Live Zoom link | Passcode: BearDown
(Instructor permission required for enrolled students to attend via Zoom)
Hosts: Dr. Beth Hutchinson and Dr. Shang Song
Persons with a disability may request a reasonable accommodation by contacting the Disability Resource Center at 621-3268 (V/TTY).
ABSTRACT: The brain has all of the hallmarks of a complex system, with meaningful activity occurring at a wide range of spatial and temporal scales. When measured with resting state fMRI, all of this activity is compressed into a single measurement of the resulting hemodynamic response for each voxel at each time point. However, using multimodal preclinical neuroimaging techniques and leveraging the spatial, temporal and spectral properties of different types of activity, we may be able to identify signatures in the rs-fMRI signal. In this talk, I will describe some of the types of activity that we expect to contribute to the rs-fMRI signal and features that might allow us to selectively extract them for use in research or the clinic.
BIO: Shella Keilholz obtained her B.S. in physics from the University of Missouri—Rolla (now Missouri University of Science and Technology). Her Ph.D. in engineering physics at the University of Virginia focused on quantitative measurements of perfusion with arterial spin labeling MRI. After graduation, she went to the NIH as a post-doctoral researcher in Dr. Alan Koretsky’s lab to learn functional neuroimaging. She is currently a professor in the joint Emory
University/Georgia Tech Biomedical Engineering Department. Her research seeks to elucidate the neurophysiological processes that underlie the BOLD signal and develop analytical techniques that leverage spatial and temporal information to separate contributions from different sources.