BME Seminar: Curtis A. Thorne
Monday, November 13, 2023 - 12:00 p.m.
Curtis A. Thorne
Associate Professor
Cellular & Molecular Medicine
University of Arizona
“Multiscale Feedback Regulating Cell Communication Inorganoids“
Keating 103 | Zoom link, Password: BearDown
Hosts: Dr. Mario Romero-Ortega and Dr. Shang Song
(Instructor permission required for enrolled students to attend via Zoom)
Persons with a disability may request a reasonable accommodation by contacting the Disability Resource Center at 621-3268 (V/TTY).
Abstract:
Regenerative tissues require layers of signaling to maintain a steady state of form and function. Signaling can occur intracellularly or among a community of cells.The Wnt signaling pathway is a critical regulator of stem cell fate required for tissue maintenance. Misregulation of Wnt can lead to cancer in most tissues. I will discuss our work on revealing feedback control mechanisms that support robust Wnt signaling at the single-cell and tissue levels and how patient-derived organoids facilitate this work.
Bio:
Curtis A. Thorne received his BS in biology from Baylor University in 2000. He worked at Baylor College of Medicine studying breast cancer under the direction of Dr. Adrian Lee. His graduate studies were under the direction of Dr. Ethan Lee in Wnt signaling at Vanderbilt University. Thorne received his Ph.D. in 2010. He conducted postdoctoral studies as an American Cancer Society Fellow at the University of Texas Southwestern in Dr. Steven Altschuler and Dr. Lani Wu’s laboratories, studying intestinal stem cells and colon cancer. In 2017, Curtis moved to the University of Arizona as an assistant professor in the Department of Cellular and Molecular Medicine and member of the Cancer Center.