Ronald M. Lynch
Professor of Physiology
Associate Professor of Pharmacology
Professor, BIO5 Institute
Professor of Biomedical Engineering
Professor, Physiological Sciences Graduate Interdisciplinary Program
Director, ARIBI Institute
Associate Director, UA Cancer Center Shared Resources
Dr. Ronald Lynch received a Ph.D. in Physiology and Biophysics at the University of Cincinnati in 1984. He began training in optical imaging and MR spectroscopy of cardiac metabolism while at the NIH under the direction of Dr. Robert Balaban from 1984-1987. In 1987 Dr. Lynch moved to a staff position in the Biomedical Imaging Group with appointment in the Physiology Department at the University of Massachusetts Medical Center under the direction of Dr. Fredric S. Fay. While there, Dr. Lynch was involved in developing approaches for 3-dimensional optical imaging including deconvolution and confocal microscopy. In 1990 Dr. Lynch was recruited to the University of Arizona to develop a research program centered on the use and development of microscopic imaging and spectroscopy to study physiological problems. In 2000, Dr. Lynch was a visiting scientist at the Laboratory of Functional Molecular Imaging and the Magnetic Resonance Imaging Center with Dr. Alan Koretsky at the NIH.
Dr. Lynch’s primary appointment is in Physiology, with joint appointments in Biomedical Engineering and Medical Pharmacology. He currently is the Director of the Arizona Research Institute for Biomedical Imaging (ARIBI), and is a member of the Arizona Cancer Center and Sarver Heart Center.
Research in the Lynch lab focuses on second messenger signaling in vascular smooth muscle cells and nutrient sensing cells (e.g., Pancreatic Beta-cells) with emphasis on alterations in signaling that occur during development of Diabetes. Under development are methods to modify and analyze beta cell mass in order to evaluate the initiation of the pre-diabetic state, and efficacy of its treatment. Analyses of subcellular protein distributions, second messenger signaling, and ligand binding are performed using state of the art microscopy and analysis approaches which is a second area of expertise. Over the past 3 decades, the Lynch lab has worked on developing unique microscopic imaging and spectroscopy approaches to study cell and tissue function, as well as screening assays for cell signaling and ligand binding
BME 511: Physiology for Bioengineers
PSIO 603: Human Systems Physiology; Gastrointestinal Physiology Section
PSIO 503: Cellular and Molecular Physiology: Cell Organization and Signaling Section
Medical Physiology: Digestion, Metabolism and Hormones, Sections I and II.
Research Website: http://lynchlab.arizona.edu/ronald_lynch_research_lab
- Ph.D. Physiology and Biophysics
- University of Cincinnati, Cincinnati, Ohio, USA
- Energy transduction in vascular smooth muscle: compartmentation of carbohydrate metabolism
- B.S. Chemistry and Biology
- University of Miami, Miami, Florida, United States
- Director, Arizona Research Institute for Biomedical Imaging (ARIBI), University of Arizona, Tucson, Arizona (2007 - Ongoing)
- Chair, Physiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona (2006 - 2012)
- Professor, Physiology and Pharmacology, University of Arizona, Tucson, Arizona (2004 - Ongoing)
- Director, Imaging Core Facility, University of Arizona, Cancer Center (2001 - Ongoing)
- Special Volunteer, Laboratory of Functional & Molecular Imaging, National Institutes of Health, NINDS (2001 - 2005)
- Visiting Scientist, Laboratory of Functional & Molecular Imaging, National Institutes of Health, NINDS (2000 - 2001)
- Associate Professor, Physiology and Pharmacology, University of Arizona, Tucson, Arizona (1996 - 2003)
- Assistant Professor, Departments of Physiology and Pharmacology, University of Arizona, Tucson, Arizona (1991 - 1996)
- Instructor, Physiology, and Biomedical Imaging Group, Univ. Massachusetts, Medical Ctr (1987 - 1990)
- Senior Staff Fellow,, Laboratory of Cardiac Energetics, National Institutes of Health (1987 - 1987)
- Post Doctoral Fellow, Laboratory of Kidney & Electrolyte Metabolism, National Institutes of Health, NHLBI (1984 - 1987)
PSIO 603A (Spring 2019)
PSIO 603A (Spring 2018)
PSIO 603A (Spring 2017)
PSIO 511 (Spring 2019)
BME 511 (Spring 2019)
BME 511 (Spring 2018)
PSIO 511 (Spring 2018)
BME 511 (Spring 2017)
Biology For Biomed Engr
BME 510 (Fall 2018)
BME 510 (Fall 2017)
BME 510 (Fall 2016)
PSIO 503 (Fall 2018)
PS 503 (Fall 2018)
PSIO 503 (Fall 2017)
PSIO 503 (Fall 2016)
Honors Independent Study
BIOC 299H (Spring 2018)
BIOC 299H (Fall 2017)
BIOC 499H (Spring 2017)
BIOC 299H (Spring 2017)
BIOC 499H (Fall 2016)
BIOC 498 (Spring 2018)
BIOC 498 (Fall 2017)
BIOC 498H (Spring 2018)
BIOC 498H (Fall 2017)
BIOC 492 (Fall 2017)
BIOC 492 (Spring 2017)
BIOC 492 (Fall 2016)
PSIO 920 (Fall 2016)
PSIO 900 (Summer I 2016)
- Kelly, A. C., Smith, K. E., Purvis, W. G., Min, C. G., Weber, C. S., Cooksey, A. M., Hasilo, C., Paraskevas, S., Suszynski, T. M., Weegman, B. P., Anderson, M. J., Camacho, L. E., Harland, R. C., Loudovaris, T., Jandova, J., Molano, D. S., Price, N. D., Georgiev, I. G., Scott, W. E., , Manas, D. M., et al. (2019). Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling. Transplantation, 103(1), 160-167.
- Hart, N. J., Weber, C., Papas, K. K., Limesand, S. W., Vagner, J., & Lynch, R. M. (2018). Multivalent activation of GLP-1 and Sulfonylurea receptors modulates β-cell Second Messenger Signaling and Insulin Secretion. American journal of physiology. Cell physiology.
- Kelly, A. C., Camacho, L. E., Pendarvis, K., Davenport, H. M., Steffens, N. R., Smith, K. E., Weber, C. S., Lynch, R. M., Papas, K. K., & Limesand, S. W. (2018). Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells. Molecular and cellular endocrinology.
- Smith, K. E., Purvis, W. G., Davis, M. A., Min, C. G., Cooksey, A. M., Weber, C. S., Jandova, J., Price, N. D., Molano, D. S., Stanton, J. B., Kelly, A. C., Steyn, L. V., Lynch, R. M., Limesand, S. W., Alexander, M., Lakey, J. R., Seeberger, K., Korbutt, G. S., Mueller, K. R., , Hering, B. J., et al. (2018). In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes. Xenotransplantation, 25(6), e12432.
- Chen, X., Kelly, A. C., Yates, D. T., Macko, A. R., Lynch, R. M., & Limesand, S. W. (2017). Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine. The Journal of endocrinology, 232(2), 285-295.
- McKay, B. S., Lynch, R. M., & Stamer, W. D. (2017). Comment on "Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism". Investigative ophthalmology & visual science, 58(11), 4733-4734.
- Smith, K. E., Kelly, A. C., Min, C. G., Weber, C. S., McCarthy, F. M., Steyn, L. V., Badarinarayana, V., Stanton, J. B., Kitzmann, J. P., Strop, P., Gruessner, A. C., Lynch, R. M., Limesand, S. W., & Papas, K. K. (2017). Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans. Transplantation, 101(11), 2705-2712.
- Dehigaspitiya, D. C., Anglin, B. L., Smith, K. R., Weber, C. S., Lynch, R. M., & Mash, E. A. (2015). Linear scaffolds for multivalent targeting of melanocortin receptors. Organic & biomolecular chemistry, 13(47), 11507-17.
- Dehigaspitiya, D. C., Navath, S., Weber, C. S., Lynch, R. M., & Mash, E. A. (2015). Synthesis and bioactivity of MSH4 oligomers prepared by an A2 + B2 strategy. Tetrahedron letters, 56(23), 3060-3065.
- Elshan, N. G., Jayasundera, T., Anglin, B. L., Weber, C. S., Lynch, R. M., & Mash, E. A. (2015). Trigonal scaffolds for multivalent targeting of melanocortin receptors. Organic & biomolecular chemistry, 13(6), 1778-91.
- Elshan, N. G., Jayasundera, T., Weber, C. S., Lynch, R. M., & Mash, E. A. (2015). Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor. Bioorganic & medicinal chemistry, 23(8), 1841-8.
- Marmorstein, A. D., Kinnick, T. R., Stanton, J. B., Johnson, A. A., Lynch, R. M., & Marmorstein, L. Y. (2015). Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium. Molecular vision, 21, 347-59.
- Steyn, L. V., Ananthakrishnan, K., Anderson, M. J., Patek, R., Kelly, A., Vagner, J., Lynch, R. M., & Limesand, S. W. (2015). A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.
- Wojtkowiak, J. W., Cornnell, H. C., Matsumoto, S., Saito, K., Takakusagi, Y., Dutta, P., Kim, M., Zhang, X., Leos, R., Bailey, K. M., Martinez, G., Lloyd, M. C., Weber, C., Mitchell, J. B., Lynch, R. M., Baker, A. F., Gatenby, R. A., Rejniak, K. A., Hart, C., , Krishna, M. C., et al. (2015). Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302. Cancer & metabolism, 3(1), 2.
- Hart, N. J., Chung, W. J., Weber, C., Ananthakrishnan, K., Anderson, M., Patek, R., Zhang, Z., Limesand, S. W., Vagner, J., & Lynch, R. M. (2014). Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells. Chembiochem : a European journal of chemical biology, 15(1), 135-45.
- Lynch, R. M. (2016, August). Molecular Theranostics: Targeting Receptor Combinations with Multivalent Agents. PhysSoc Mtg.. Dublin, IRE: The Physiological Society.
- Lynch, R. M. (2016, March). Multivalent Agents for Targeted Therapy and Diagnostics of Metabolic Diseases. Physiology Seminar. North Chicago, IL: Rosiland Franklin University Collge of Medcine.
- Lynch, R. M. (2015, Apr 2., 2015). Accessing the molecular barcode: multivalent ligands for beta-cell specific targeting and therapeutics. American Physiological Society Symposium: Rejuvenating the beta-cell. Boston, MA: Experimental Biology.
- Lynch, R. M. (2015, Sept 13, 2015). Title: Multivalent approaches for beta-cell specific targeting. Symposium: Beta cell Imaging. Stockholm Sweden: BetaTrain, European Diabetes Association.
- Lynch, R. M. (2014, July). Invited Speaker. Seminar: St. Vincent's Research Institute. Melbourne, AUS: St. Vincent's Research Institute;.
- Lynch, R. M. (2014, June). Invited Speaker. Seminar: IMB Division of Chemistry and Human Therapeutics. Brisbane, AUS: Univ. Queensland,.
- Lynch, R. M. (2014, June). Invited Speaker. Seminar: Translational Research Institute, University of Queensland, AUS.
- Lynch, R. M. (2014, May). Invited Speaker. Symposium: Imaging and Energetics. National institutes of Health , Bethesda, MD: National institutes of Health.
- Lynch, R. M. (2014, October). Invited Speaker. Cayman Peptide Meeting. St. Croix VI: Cayman Peptide Meeting.
- Furrow Award: for Excellence in Graduate Education
- University of Arizona, College of Medicine, Fall 2014