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Medical Research Building 320
John P. Konhilas
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Acting Program Director of Physiology
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Associate Professor of Physiology
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Associate Professor of Biomedical Engineering
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Associate Professor of Cellular and Molecular Medicine
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Associate Professor of Nutritional Sciences
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Chair, Physiological Sciences Graduate Interdisciplinary Program
- Gut microbiome and cardiac remodeling. Our lab has a long-standing interest in the ability of environmental factors, like diet, to impact cardiac disease. Advances in sequencing and bioinformatic technologies have allowed unprecedented characterization of the gut microbiome. We have discovered novel modifiers of the gut microbiome that protect against cardiac injury following ischemia.
- Sarcomere dynamics and crossbridge kinetics. Contractile perturbations downstream of Ca2+ binding to troponin C, the so-called sarcomere-controlled mechanisms, represent the earliest indicators of cardiovascular disease. We can now state the dynamics of cardiac contraction and relaxation during CVD are governed by downstream mechanisms, particularly the kinetics and energetics of the cross-bridge cycle. Our lab focuses on the contractile properties of the cardiomyocyte and how this changes with CVD.
- Sex dimorphisms in cardiac adaptation.Sex/gender differences exist in human cardiac disease resulting from many disease etoilogies including hypertension, myocardial infarction, and cardiomyopathies (HCM). We have adapted a novel model of menopause to uniquely address HCM and CVD, in general. As part of these studies, we became interested in a specific, energy-dependent signaling pathway, adenosine monophosphate-activated kinase (AMPK) demonstrating that AMPK regulates contractile function and energy cost of contraction.
- Predicting and mitigating postoperative surgical outcomes. (1) Cognitive impairment resulting from cardiac bypass surgery. Although treatment strategies for cardiovascular disease (CVD) are improving, coronary revascularization remains one of the most common interventional procedures. Following CABG surgery, cognitive impairment is reported in 50-75% of patients at discharge, 20-50% at 6 weeks and up to 40% at five years. Exciting new preclinical data from our group shows that systemic administration of Ang-(1-7) attenuates and even reverses CHF-induced cognitive impairment in mice. Our work has resulted in 2 patent applications (UA13-120 UA 14-167) and an IND application for the for Ang-(1-7) as a protective agent against CABG-induced cognitive impairment. (2) Predicting and mitigating postoperative new onset atrial fibrillation and cardiac remodeling. We have discovered a potential use for Human Amniotic Membranes for the prevention of postoperative (bypass surgery) outcomes. In human subjects, membrane placement during CABG preventative new onset postoperative atrial fibrillation. In mice, we prevented wall thinning post-myocardial infarction.
Degrees
- Ph.D. Physiology and Biophysics
- University of Illinois at Chicago, Chicago, Illinois, United States
- The Molecular Mechanisms of Length-Dependent Activation in Striated Muscle
- M.S. Biological Sciences
- University of Illinois at Chicago, Chicago, Illinois, United States
- The Dynamics of Spherical Elastic Systems and its Significance to the Left Ventricular End-Systolic Pressure-Volume Relation
- Certificate in Neurosciences Neuroscience
- Duke University, Durham, North Carolina, United States
- B.A. Art and Art History
- Duke University, Durham, North Carolina, United States
Courses
Independent Study
MCB 299 (Fall 2016)
MCB 399 (Fall 2017)
MCB 499 (Spring 2017)
PSIO 399 (Spring 2022)
PSIO 399 (Spring 2021)
PSIO 399 (Fall 2020)
PSIO 399 (Spring 2020)
PSIO 399 (Summer I 2019)
PSIO 399 (Fall 2016)
PSIO 499 (Fall 2023)
PSIO 499 (Fall 2022)
PSIO 499 (Spring 2020)
Honors Independent Study
BIOC 499H (Spring 2018)
BIOC 499H (Fall 2017)
ECOL 299H (Spring 2020)
ECOL 399H (Spring 2021)
ECOL 399H (Fall 2020)
MCB 499H (Spring 2020)
MCB 499H (Fall 2019)
MCB 499H (Fall 2017)
PSIO 399H (Spring 2023)
PSIO 399H (Spring 2020)
PSIO 399H (Fall 2019)
PSIO 399H (Spring 2019)
PSIO 399H (Fall 2018)
PSIO 399H (Spring 2017)
PSIO 399H (Fall 2016)
PSIO 499H (Spring 2024)
PSIO 499H (Fall 2023)
PSIO 499H (Spring 2021)
PSIO 499H (Fall 2020)
PSIO 499H (Spring 2020)
PSIO 499H (Fall 2019)
Integrative Cell Psio
PSIO 303B (Spring 2016)
Cardio Muscle Bio & Disease
BME 484 (Spring 2024)
BME 484 (Spring 2023)
BME 484 (Spring 2022)
BME 484 (Spring 2021)
BME 484 (Spring 2020)
BME 484 (Spring 2017)
BME 484 (Spring 2016)
BME 584 (Spring 2024)
BME 584 (Spring 2023)
BME 584 (Spring 2022)
BME 584 (Spring 2021)
BME 584 (Spring 2020)
BME 584 (Spring 2017)
BME 584 (Spring 2016)
CMM 484 (Spring 2024)
CMM 484 (Spring 2020)
CMM 584 (Spring 2024)
CMM 584 (Spring 2022)
CMM 584 (Spring 2021)
CMM 584 (Spring 2020)
CMM 584 (Spring 2019)
CMM 584 (Spring 2017)
MCB 484 (Spring 2023)
MCB 484 (Spring 2021)
MCB 484 (Spring 2020)
MCB 484 (Spring 2019)
MCB 484 (Spring 2016)
MCB 584 (Spring 2021)
PSIO 484 (Spring 2024)
PSIO 484 (Spring 2023)
PSIO 484 (Spring 2022)
PSIO 484 (Spring 2021)
PSIO 484 (Spring 2020)
PSIO 484 (Spring 2019)
PSIO 484 (Spring 2018)
PSIO 484 (Spring 2017)
PSIO 484 (Spring 2016)
PSIO 584 (Spring 2024)
PSIO 584 (Spring 2023)
PSIO 584 (Spring 2022)
PSIO 584 (Spring 2021)
PSIO 584 (Spring 2019)
PSIO 584 (Spring 2018)
PSIO 584 (Spring 2016)
Directed Research
MCB 792 (Fall 2020)
PSIO 492 (Fall 2023)
PSIO 492 (Spring 2023)
PSIO 492 (Spring 2022)
PSIO 492 (Fall 2021)
PSIO 492 (Spring 2021)
PSIO 492 (Fall 2020)
PSIO 492 (Spring 2020)
PSIO 492 (Fall 2018)
PSIO 492 (Spring 2017)
Sex Matters in Medicine
PSIO 495S (Fall 2024)
PSIO 595S (Fall 2024)
Senior Capstone
MCB 498 (Spring 2016)
Honors Thesis
BIOC 498H (Spring 2019)
BIOC 498H (Fall 2018)
ECOL 498H (Spring 2022)
ECOL 498H (Fall 2021)
MCB 498H (Spring 2021)
MCB 498H (Fall 2020)
PSIO 498H (Spring 2022)
PSIO 498H (Fall 2021)
PSIO 498H (Spring 2021)
PSIO 498H (Fall 2020)
PSIO 498H (Fall 2018)
PSIO 498H (Spring 2018)
PSIO 498H (Fall 2017)
PSIO 498H (Spring 2017)
PSIO 498H (Fall 2016)
Biology For Biomed Engr
BME 510 (Fall 2023)
BME 510 (Fall 2021)
BME 510 (Fall 2019)
BME 510 (Fall 2018)
BME 510 (Fall 2017)
BME 510 (Fall 2016)
Physiology/Biomed Engr
BME 511 (Spring 2024)
BME 511 (Spring 2023)
BME 511 (Spring 2022)
BME 511 (Spring 2021)
BME 511 (Spring 2020)
BME 511 (Spring 2019)
BME 511 (Spring 2018)
BME 511 (Spring 2017)
BME 511 (Spring 2016)
PSIO 511 (Spring 2024)
PSIO 511 (Spring 2023)
PSIO 511 (Spring 2022)
PSIO 511 (Spring 2021)
PSIO 511 (Spring 2020)
PSIO 511 (Spring 2019)
PSIO 511 (Spring 2018)
Rsrch Meth Biomed Engr
BME 597G (Spring 2018)
BME 597G (Fall 2017)
BME 597G (Spring 2016)
Human Physiology
PSIO 603A (Spring 2024)
PSIO 603A (Spring 2023)
PSIO 603A (Spring 2022)
PSIO 603A (Spring 2021)
PSIO 603A (Spring 2020)
PSIO 603A (Spring 2019)
PSIO 603A (Spring 2018)
PSIO 603A (Spring 2017)
PSIO 603A (Spring 2016)
Research Methods In Psio
PSIO 610 (Fall 2017)
Physiology Series
PSIO 696A (Spring 2019)
PSIO 696A (Fall 2018)
PSIO 696A (Spring 2018)
PSIO 696A (Fall 2017)
Physiology Student Forum
PS 696C (Spring 2019)
PS 696C (Fall 2018)
PS 696C (Spring 2018)
PS 696C (Fall 2017)
PSIO 696C (Fall 2018)
PSIO 696C (Spring 2018)
PSIO 696C (Fall 2017)
Rsrch Meth Psio Sci
PS 700 (Spring 2024)
PS 700 (Fall 2023)
PS 700 (Fall 2021)
PS 700 (Fall 2020)
PS 700 (Fall 2018)
Research
NSC 900 (Spring 2018)
PS 900 (Fall 2024)
PS 900 (Fall 2023)
PS 900 (Spring 2023)
PS 900 (Fall 2022)
PS 900 (Spring 2022)
PS 900 (Fall 2021)
PS 900 (Spring 2021)
PS 900 (Fall 2020)
PS 900 (Fall 2019)
PS 900 (Summer I 2019)
PS 900 (Spring 2019)
PS 900 (Fall 2018)
PSIO 900 (Spring 2018)
PSIO 900 (Fall 2017)
PSIO 900 (Summer I 2016)
Thesis
BME 910 (Spring 2019)
BME 910 (Fall 2018)
CMM 910 (Spring 2022)
CMM 910 (Spring 2021)
NSC 910 (Spring 2018)
NSC 910 (Fall 2017)
NSC 910 (Spring 2017)
NSC 910 (Fall 2016)
PS 910 (Spring 2022)
PS 910 (Fall 2021)
Dissertation
BME 920 (Spring 2020)
BME 920 (Fall 2019)
BME 920 (Spring 2019)
BME 920 (Fall 2018)
BME 920 (Spring 2018)
BME 920 (Fall 2017)
CMM 920 (Spring 2024)
CMM 920 (Fall 2023)
CMM 920 (Spring 2023)
CMM 920 (Fall 2022)
CMM 920 (Spring 2022)
CMM 920 (Fall 2021)
CMM 920 (Spring 2021)
CMM 920 (Fall 2020)
CMM 920 (Spring 2020)
NSC 920 (Spring 2021)
NSC 920 (Fall 2020)
NSC 920 (Spring 2020)
NSC 920 (Fall 2019)
NSC 920 (Spring 2019)
NSC 920 (Spring 2018)
NSC 920 (Fall 2017)
PS 920 (Spring 2024)
PS 920 (Fall 2023)
PS 920 (Spring 2023)
PS 920 (Fall 2022)
PS 920 (Spring 2022)
PS 920 (Fall 2021)
PS 920 (Spring 2020)
PS 920 (Fall 2019)
Selected Publications
Chapters
- Lopez-Pier, M., Lipovka, Y., & Konhilas, J. P. (2016). Inherited Cardiomyopathies. In Cardiomyopathies. Intech Publishing.
Journals/Publications
- Hoyer-Kimura, C., Konhilas, J., Pires, P., Banek, C., Dennis, M., Salcedo, V., & Hay, M. (2023).
A novel therapeutic Ang(1-7) analogue improves neurovascular function in mice with vascular contributions to cognitive impairment and dementia
. Physiology, 38(S1). doi:10.1152/physiol.2023.38.s1.5735136
- Hoyer-Kimura, C., Langlas, P., Lopez-Schultz, M., Salcedo, V., Fricks, J., & Konhilas, J. (2023).
Sex, age and menopause differentially impact gut barrier function and proteomic profile
. Physiology, 38(S1). doi:10.1152/physiol.2023.38.s1.5735182
- Skaria, R. S., Lopez‐Pier, M. A., Kathuria, B. S., Leber, C. J., Langlais, P. R., Aras, S. G., Khalpey, Z. I., Hitscherich, P. G., Chnari, E., Long, M., Churko, J. M., Runyan, R. B., & Konhilas, J. P. (2023).
Epicardial placement of human placental membrane protects from heart injury in a swine model of myocardial infarction
. Physiological Reports, 11(20). doi:10.14814/phy2.15838
- Hay, M., Sweitzer, N., Konhilas, J., Hoyer‐Kimura, C., & Ryan, L. (2022). Circulating neurodegeneration biomarkers neurofilament light protein and p‐tau181 are increased in individuals with heart failure at risk for vascular cognitive impairment. Alzheimer's & Dementia, 18(S5). doi:10.1002/alz.059920
- Keresztes, A., Olson, K., Nguyen, P., Lopez-Pier, M. A., Hecksel, R., Barker, N. K., Liu, Z., Hruby, V., Konhilas, J., Langlais, P. R., & Streicher, J. M. (2022). Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling. Pain, 163(1), 146-158.
- Streicher, J. M., Langlais, P. R., Konhilas, J. P., Hruby, V., Liu, Z., Barker, N. K., Hecksel, R., Lopez-Pier, M. A., Nguyen, P., Olson, K., & Keresztes, A. (2022). Antagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling. Pain.
- Celli, B., McCormack, M., Rahman, I., Schnellmann, R. G., Langlais, P. R., Konhilas, J. P., Zmijewski, J., Casanova, C., Ledford, J., Tesfaigzi, Y., Sauler, M., Doubleday, K., Hansel, N. N., Hersh, C. P., Kinney, G. L., Fawzy, A., Owen, C. A., Cordoba-Lanus, E., Cleveland, K., , Zhang, D., et al. (2020). Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. American Journal of Respiratory and Critical Care Medicine.
- Hay, M., Ryan, L., Huentelman, M., Konhilas, J., Hoyer-Kimura, C., Beach, T. G., Serrano, G. E., Reiman, E. M., Blennow, K., Zetterberg, H., & Parthasarathy, S. (2021). Serum Neurofilament Light is elevated in COVID-19 Positive Adults in the ICU and is associated with Co-Morbid Cardiovascular Disease, Neurological Complications, and Acuity of Illness. Cardiology and cardiovascular medicine, 5(5), 551-565.
- Hoyer-Kimura, C., Konhilas, J. P., Mansour, H. M., Polt, R., Doyle, K. P., Billheimer, D., & Hay, M. (2021). Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia. Journal of neuroinflammation, 18(1), 236.
- Iwanski, J., Kazmouz, S. G., Li, S., Stansfield, B., Salem, T. T., Perez-Miller, S., Kazui, T., Jena, L., Uhrlaub, J. L., Lick, S., Nikolich-Žugich, J., Konhilas, J. P., Gregorio, C. C., Khanna, M., Campos, S. K., & Churko, J. M. (2021). Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells. Stem cell reports, 16(10), 2459-2472.
- Konhilas, J. P., Hoyer-Kimura, C. H., Behm, C., Fricks, J. P., & Duca, F. (2021). Abstract P481: Short-term Synbiotic, B420 And Oligofructose, Treatment Reverse High-fat-diet Related Pathologies In Ischemic Reperfusion Mouse Models. Circulation Research, 129(Suppl_1). doi:10.1161/res.129.suppl_1.p481
- Konhilas, J. P., Solomon, A. E., Hoyer-Kimura, C., Kangath, A., & Duca, F. (2021). Abstract P366: The Impact Of Estrogen Signaling On Gut Epithelial Cells. Circulation Research, 129(Suppl_1). doi:10.1161/res.129.suppl_1.p366
- Lopez-Pier, M. A., Koppinger, M. P., Harris, P. R., Cannon, D. K., Skaria, R. S., Hurwitz, B. L., Watts, G., Aras, S., Slepian, M. J., & Konhilas, J. P. (2021). An adaptable and non-invasive method for tracking Bifidobacterium animalis subspecies lactis 420 in the mouse gut. Journal of microbiological methods, 189, 106302.
- McCormack, M., Schnellmann, R., Konhilas, J., Ledford, J. G., Hansel, N. N., Fawzy, A., Polverino, F., Wu, T. D., Rojas-Quintero, J., Wang, X., Mayo, J., Tomchaney, M., Tram, J., Packard, S., Zhang, D., Cleveland, K. H., Cordoba-Lanus, E., Owen, C. A., Kinney, G. L., , Hersh, C. P., et al. (2021). Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. American Journal of Respiratory and Critical Care Medicine, 204(6), 651-666. doi:10.1164/rccm.202012-4510oc
- Polverino, F., Wu, T. D., Rojas-Quintero, J., Wang, X., Mayo, J., Tomchaney, M., Tram, J., Packard, S., Zhang, D., Cleveland, K. H., Cordoba-Lanus, E., Owen, C. A., Fawzy, A., Kinney, G. L., Hersh, C. P., Hansel, N. N., Doubleday, K., Sauler, M., Tesfaigzi, Y., , Ledford, J. G., et al. (2021). Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. American journal of respiratory and critical care medicine, 204(6), 651-666.
Proceedings Publications
- Konhilas, J. (2020). Decision letter: Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload. In Elife review.
- Wolfkiel, C. J., Konhilas, J. P., & Holt, W. W. (1995). Regional pulmonary blood flow measurement in humans with electron-beam computed tomography. In Medical Imaging 1995: Physiology and Function from Multidimensional Images, 2433, 15-25.
Poster Presentations
- Fricks, J., Salcedo, V., Pier, M., Langlais, P. R., Konhilas, J. P., & Hoyer-Kimura, C. (2022, October). Estrogen Status in Menopause and Sex Differences within the Gut Promote Functionally Distinct Changes. Arizona Physiological Society.
- Hay, M., Hay, M., Doyle, K., Doyle, K., Ossanna, N., Ossanna, N., Falk, T., Falk, T., Bartlett, M., Bartlett, M., Polt, R. L., Polt, R. L., Mansour, H. M., Mansour, H. M., Konhilas, J. P., Konhilas, J. P., Hoyer-Kimura, C., & Hoyer-Kimura, C. (2021, March/Spring). Novel Therapeutic and Inflammatory Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia.. AD/PD 2021 15th International Conference on Alzheimer’s and Parkinson’s Diseases Virtual ConferenceAD/PD.
- Chung, A., Frye, J. B., Zbesko, J. C., Constantopoulos, E., Hayes, M. I., Figueroa, A. G., Day, W. A., Konhilas, J. P., Mckay, B. S., Nguyen, T., & Doyle, K. (2018, June). Liquefaction of the brain following stroke shares a similar molecular and morphological profile with atherosclerosis and mediates secondary neurodegeneration in an osteopontin dependent mechanism. Keystone Symposia Conference: New Frontiers in Neuroinflammation: What Happens when CNS and Periphery Meet?. Keystone, Colorado: Keystone Symposia Conference.
- Chung, A., Frye, J. B., Zbesko, J. C., Constantopoulos, E., Hayes, M. I., Figueroa, A. G., Day, W. A., Konhilas, J. P., Mckay, B. S., Nguyen, T., & Doyle, K. (2018, November). Liquefaction of the brain following stroke shares characteristics with atherosclerosis. Society for Neuroscience Conference. San Diego, California: Society for Neuroscience.
- Lopez-Pier, M., Cannon, D., Langlais, P. R., & Konhilas, J. P. (2018, October/Fall). AMP activated Protein Kinase and Estrogen-depednent mechanisms underlying increased susceptibility to CVD during Menopause. University of Arizona Biomedical Engineering Student Poster Session.