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Medical Research Building 325
Henk L. Granzier
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Professor of Cellular and Molecular Medicine
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Professor of Biomedical Engineering
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Professor of Physiology
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Professor of Molecular and Cellular Biology
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Professor, Physiological Sciences Graduate Interdisciplinary Program
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Professor, BIO5 Institute
Degrees
- Ph.D. Bioengineering
- University of Washington, Seattle, Washington, United States
Work Experience
- University of Arizona, Tucson, Arizona (2007 - Ongoing)
- Washington State University, Pullman, Washington (1993 - 2007)
Courses
Honors Independent Study
MCB 199H (Spring 2024)
MCB 299H (Spring 2019)
PSIO 399H (Fall 2023)
PSIO 399H (Fall 2019)
Directed Rsrch
MCB 392 (Summer I 2018)
MCB 492 (Fall 2018)
Directed Research
BIOC 392 (Fall 2018)
BIOC 492 (Spring 2019)
BME 492 (Spring 2017)
BME 492 (Fall 2016)
MCB 792 (Fall 2021)
Cardio Muscle Bio & Disease
BME 484 (Spring 2024)
BME 484 (Spring 2023)
BME 484 (Spring 2022)
BME 484 (Spring 2021)
BME 484 (Spring 2020)
BME 484 (Spring 2017)
BME 484 (Spring 2016)
BME 584 (Spring 2024)
BME 584 (Spring 2023)
BME 584 (Spring 2022)
BME 584 (Spring 2021)
BME 584 (Spring 2020)
BME 584 (Spring 2017)
BME 584 (Spring 2016)
CMM 484 (Spring 2024)
CMM 484 (Spring 2020)
CMM 584 (Spring 2024)
CMM 584 (Spring 2022)
CMM 584 (Spring 2021)
CMM 584 (Spring 2020)
CMM 584 (Spring 2019)
CMM 584 (Spring 2017)
MCB 484 (Spring 2023)
MCB 484 (Spring 2021)
MCB 484 (Spring 2020)
MCB 484 (Spring 2019)
MCB 484 (Spring 2016)
MCB 584 (Spring 2021)
PSIO 484 (Spring 2024)
PSIO 484 (Spring 2023)
PSIO 484 (Spring 2022)
PSIO 484 (Spring 2021)
PSIO 484 (Spring 2020)
PSIO 484 (Spring 2019)
PSIO 484 (Spring 2018)
PSIO 484 (Spring 2017)
PSIO 484 (Spring 2016)
PSIO 584 (Spring 2024)
PSIO 584 (Spring 2023)
PSIO 584 (Spring 2022)
PSIO 584 (Spring 2021)
PSIO 584 (Spring 2019)
PSIO 584 (Spring 2018)
PSIO 584 (Spring 2016)
Senior Capstone
BIOC 498 (Spring 2020)
BIOC 498 (Fall 2019)
BIOC 498 (Spring 2018)
BIOC 498 (Fall 2017)
Honors Thesis
ECOL 498H (Spring 2024)
ECOL 498H (Fall 2023)
PSIO 498H (Spring 2021)
PSIO 498H (Fall 2020)
PSIO 498H (Spring 2016)
Independent Study
CMM 499 (Spring 2016)
Rsrch Meth Psio Sci
PS 700 (Spring 2022)
PS 700 (Fall 2016)
Introduction to Research
MCB 795A (Fall 2018)
MCB 795A (Fall 2017)
Research
CMM 900 (Spring 2023)
CMM 900 (Fall 2022)
CMM 900 (Spring 2021)
CMM 900 (Fall 2020)
CMM 900 (Spring 2020)
CMM 900 (Fall 2019)
GENE 900 (Fall 2021)
GENE 900 (Fall 2020)
PS 900 (Spring 2018)
PS 900 (Fall 2017)
PS 900 (Spring 2017)
Thesis
CMM 910 (Fall 2021)
Dissertation
BME 920 (Spring 2021)
BME 920 (Fall 2020)
BME 920 (Spring 2020)
BME 920 (Fall 2019)
BME 920 (Spring 2019)
BME 920 (Fall 2018)
BME 920 (Spring 2018)
BME 920 (Fall 2017)
BME 920 (Spring 2017)
BME 920 (Fall 2016)
BME 920 (Spring 2016)
CMM 920 (Spring 2024)
CMM 920 (Fall 2023)
CMM 920 (Spring 2018)
CMM 920 (Fall 2017)
CMM 920 (Spring 2017)
CMM 920 (Fall 2016)
CMM 920 (Spring 2016)
GENE 920 (Fall 2023)
GENE 920 (Spring 2023)
GENE 920 (Fall 2022)
PS 920 (Spring 2016)
Selected Publications
Journals/Publications
- Gregorich, Z. R., Zhang, Y., Kamp, T. J., Granzier, H., & Guo, W. (2024). Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems. Circulation. Genomic and precision medicine, e004355.
- Smith, J. E., & Granzier, H. (2024). In vivo gene editing of CAMKIID: out with the bad and in with the good. The Journal of clinical investigation, 134(1).
- Barefield, D. Y., Tonino, P., Woulfe, K. C., Rahmanseresht, S., O'Leary, T. S., Burnham, H. V., Wasserstrom, J. A., Kirk, J. A., Previs, M. J., Granzier, H. L., & McNally, E. M. (2023). Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America, 120(51), e2314920120.
- Casey, J. G., Kim, E. S., Joseph, R., Li, F., Granzier, H., & Gupta, V. A. (2023). NRAP reduction rescues sarcomere defects in nebulin-related nemaline myopathy. Human molecular genetics, 32(10), 1711-1721.
- Fukuda, N., Granzier, H., Ishiwata, S., & Morimoto, S. (2023). Editorial: Recent Advances on Myocardium Physiology, Volume II. Frontiers in physiology, 14, 1170396.
- Karimi, E., van der Borgh, M., Lindqvist, J., Gohlke, J., Hourani, Z., Kolb, J., Cossette, S., Lawlor, M. W., Ottenheijm, C., & Granzier, H. (2023). Characterization of mutations in patients reveals novel nemaline myopathy disease mechanisms and omecamtiv mecarbil force effects. bioRxiv : the preprint server for biology.
- Lindqvist, J., & Granzier, H. (2023). Pharmacological Inhibition of Myostatin in a Mouse Model of Typical Nemaline Myopathy Increases Muscle Size and Force. International journal of molecular sciences, 24(20).
- Slick, R. A., Tinklenberg, J. A., Sutton, J., Zhang, L., Meng, H., Beatka, M. J., Vanden Avond, M., Prom, M. J., Ott, E., Montanaro, F., Heisner, J., Toro, R., Granzier, H., Geurts, A. M., Stowe, D. F., Hill, R. B., & Lawlor, M. W. (2023). Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy. The American journal of pathology, 193(10), 1528-1547.
- Zhang, Y., Gregorich, Z. R., Wang, Y., Braz, C. U., Zhang, J., Liu, Y., Liu, P., Shen, J., Aori, N., Hacker, T. A., Granzier, H., & Guo, W. (2023). Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy. JCI insight, 8(13).
- Hettige, P., Mishra, D., Granzier, H., Nishikawa, K., & Gage, M. J. (2022). Contributions of Titin and Collagen to Passive Stress in Muscles from Mice with a Small Deletion in Titin's Molecular Spring. International journal of molecular sciences, 23(16).
- Lin, Y. H., Major, J. L., Liebner, T., Hourani, Z., Travers, J. G., Wennersten, S. A., Haefner, K. R., Cavasin, M. A., Wilson, C. E., Jeong, M. Y., Han, Y., Gotthardt, M., Ferguson, S. K., Ambardekar, A. V., Lam, M. P., Choudhary, C., Granzier, H. L., Woulfe, K. C., & McKinsey, T. A. (2022). HDAC6 modulates myofibril stiffness and diastolic function of the heart. The Journal of clinical investigation, 132(10).
- Lindqvist, J., Kolb, J., de Winter, J., Tonino, P., Hourani, Z., Labeit, S., Ottenheijm, C., & Granzier, H. (2022). Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits. International journal of molecular sciences, 23(15).
- Methawasin, M., Farman, G. P., Granzier-Nakajima, S., Strom, J., Kiss, B., Smith, J. E., & Granzier, H. (2022). Shortening the thick filament by partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range. Journal of molecular and cellular cardiology, 165, 103-114.
- Ranu, N., Laitila, J., Dugdale, H. F., Mariano, J., Kolb, J. S., Wallgren-Pettersson, C., Witting, N., Vissing, J., Vilchez, J. J., Fiorillo, C., Zanoteli, E., Auranen, M., Jokela, M., Tasca, G., Claeys, K. G., Voermans, N. C., Palmio, J., Huovinen, S., Moggio, M., , Beck, T. N., et al. (2022). NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy. Acta neuropathologica communications, 10(1), 185.
- Valero-Muñoz, M., Saw, E. L., Hekman, R. M., Blum, B. C., Hourani, Z., Granzier, H., Emili, A., & Sam, F. (2022). Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF). Frontiers in cardiovascular medicine, 9, 966968.
Poster Presentations
- Granzier, H. L., Smith, J. E., Kiss, B., Strom, J. G., Granzier-Nakajima, S., Farman, G. P., & Methawasin, M. (2021, September). Shortening the thick filament by partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range. International society of heart research. Denver Colorado: American Heart Association.
Presentations
- Desai, A., Sprissler, R. S., Sotak, S., Granzier, H. L., Tardiff, J. C., Khalpey, Z. I., Sweitzer, N. K., Gupta, A., Nai, V., & Whitaker, M. E. (2015, November). dult Onset Non-Ischemic Dilated Cardiomyopathy: A Novel Titin Mutation and a Case of Complex Inheritance. American College of Physicians (Arizona Chapter) Scientific Meeting. Phoenix, AZ: American College of Physicians (Arizona Chapter).
- Granzier, H. L. (2015, July). Role of titin in Heart Failure with Preserved Ejection fraction-Invited talk. BCVS-invited talk. New Orleans: AHA.
- Granzier, H. L. (2015, March 2015). Giant proteins in skeletal muscle. Bob Wade Memorial Lecture at the University of Maryland School of Medicine.. University of Maryland School of Medicine.: University of Maryland School of Medicine..
- Granzier, H. L. (2015, March). Giant proteins in skeletal muscle -invited talk. Bob Wade Memorial Lecture at the University of Maryland School of Medicine - invited talkUniversity of Maryland School of Medicine..
- Granzier, H. L. (2015, November). Role of nebulin in skeletal muscle and disease-invited talk. Invited Seminar at University of Iowa-invited. Iowa City: University of Iowa.
- Granzier, H. L. (2015, November). Titin in heart function and disease-invited talk. AHA-invited talk. Orlando, Florida: AHA.
Awards
- Henry and Phyllis Koffler Prize for research, scholarship, and creative activity
- University of Arizona, Spring 2023
- Honorary Doctorate from Semmelweis University (Budapest, Hungary).
- Semmelweis University (Budapest, Hungary), Fall 2022
- Appointed as regular Study section member
- NIH Skeletal Muscle Exercise Physiology Study Section (SMEP)-Regular Member, Spring 2022
- Honor
- American Heart Association, Fall 2018
- Invited Keynote talk Japanese Heart Association
- Japanese Heart Association, Summer I 2018
- symposia organzier
- I organized the following symposia"1. Diastolic dysfuncion symposium at ISHR, Argentina2. Symposium at myofilament meeting in Wisconsin3. Titin meeting in Chicago4. Symposium at EMC meeting in Montpellier, Francie., Summer I 2016
- 2015 Bob Wade Memorial Lecture at the University of Maryland School of Medicine
- University of Maryland, Spring 2015