Imaging biomarkers play a critical role in the diagnosis and treatment of many neurological disorders. In particular, advanced magnetic resonance imaging (MRI) biomarkers may provide valuable insight into various pathophysiological characteristics, including hemodynamic, microstructural, and functional changes. In this talk, I will discuss our work in the development of advanced acquisition and analysis approaches based on perfusion, diffusion, and functional MRI, and I will show examples of the potential role of these biomarkers in Alzheimer’s disease, multiple sclerosis, and neuro-oncology. I will also highlight our work in developing multiparametric imaging methods that better characterize complex pathologies by probing complementary features of the disease. These advanced MRI biomarkers can provide a more complete basis for understanding various neuropathologies.
Dr. Stokes received her Ph.D. in Chemistry at Duke University, where her dissertation broadly encompassed the development of advanced MRI methods for improving signal and contrast for biomedical imaging. Dr. Stokes went on to complete a post-doctoral fellowship at the Vanderbilt University Institute of Imaging Science, under the mentorship of Dr. Chad Quarles. While at Vanderbilt, Dr. Stokes was involved in the development of quantitative MRI biomarkers for neuro-oncology, including the development and validation of new acquisition and analysis methods for perfusion MRI. She was recruited to the Barrow Neurological Institute in November 2015 as part of the Barrow Neuroimaging Innovation Center. At Barrow, her lab focuses on developing advanced imaging methods for neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.
Hosts: Dr. Beth Hutchinson and Dr. Russ Witte
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