Russell Witte
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Professor of Medical Imaging
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Professor of Optical Sciences
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Professor of Biomedical Engineering
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Professor, Applied Mathematics Graduate Interdisciplinary Program
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Professor, Neuroscience Graduate Interdisciplinary Program
Russell S. Witte graduated with Honors in Physics (BS, 1993) from University of Arizona and Bioengineering (PhD, 2002) from Arizona State University, where he used electrode arrays to study sensory coding and learning-induced plasticity in the brain. As a postdoctoral fellow at the University of Michigan, he helped devise state-of-the-art techniques to image the nervous and musculoskeletal systems. Dr. Witte is now Associate Professor of Medical Imaging, Biomedical Engineering, and Optical Sciences at the University of Arizona. His Experimental Ultrasound and Neural Imaging Laboratory (EUNIL) devises hybrid imaging methods that integrate light, ultrasound, and microwaves for advanced imaging with novel contrast. These noninvasive techniques, such as acoustoelectric imaging, thermoacoustic imaging, and ultrasound elastography, quantify changes in the electrical, optical and/or mechanical properties of tissue at high spatial resolution. The ultimate goal of Dr. Witte’s research is to improve patient care by providing tools that improve diagnostic accuracy and treatment-decision making for a variety of conditions ranging from epilepsy and arrhythmia to tendinopathy and cancer.
Degrees
- Ph.D. Biomedical Engineering
- Arizona State Univeristy, Tempe, Arizona, United States
- Micro-electrode investigation of neural coding and learning-induced plasticity in auditory cortex
Interests
Teaching
• Ultrasound imaging• Functional Brain Imaging • Neural engineering• Bioelectricity ("The Body Electric")• Electromedicine/Vibrational Medicine
Research
• Hybrid modalities that combine ultrasound with light, microwaves and other forms of energy for novel contrast in biomedical imaging• Acoustoelectric Imaging for dynamic mapping of current densities in the heart and brain• Remote temperature mapping during thermal therapy• High resolution functional brain imaging • Photoacoustic imaging and spectroscopy for lymphatic imaging and tumor monitoring• Ultrasound elasticity imaging of human muscle and tendon• Novel acoustic sensors for medical applications
Courses
Honors Independent Study
BME 299H (Spring 2018)
Diagnostic Technologies
BSM 441 (Fall 2024)
Directed Research
BME 492 (Fall 2023)
BME 492 (Fall 2017)
Cnrtst Agnt Imaging+Kint
BME 522 (Spring 2022)
BME 522 (Spring 2021)
BME 522 (Spring 2020)
BME 522 (Spring 2019)
BME 524 (Spring 2018)
BME 524 (Spring 2017)
BME 524 (Spring 2016)
CBIO 522 (Spring 2020)
CBIO 524 (Spring 2017)
CBIO 524 (Spring 2016)
OPTI 522 (Spring 2021)
OPTI 522 (Spring 2020)
Rsrch Meth Biomed Engr
BME 592 (Fall 2022)
BME 592 (Spring 2022)
BME 592 (Fall 2021)
BME 592 (Fall 2020)
BME 597G (Fall 2018)
BME 597G (Fall 2017)
BME 597G (Spring 2017)
Independent Study
BME 599 (Spring 2018)
BME 599 (Fall 2017)
Advanced Medical Imaging
BME 638 (Spring 2018)
BME 638 (Spring 2016)
OPTI 638 (Spring 2023)
OPTI 638 (Spring 2021)
OPTI 638 (Spring 2019)
OPTI 638 (Spring 2018)
OPTI 638 (Spring 2016)
Biomedical Engr Seminar
BME 696A (Fall 2021)
BME 696A (Fall 2020)
Bme Student Forum
BME 696C (Spring 2022)
BME 696C (Spring 2021)
Directed Graduate Research
OPTI 792 (Spring 2023)
OPTI 792 (Fall 2022)
OPTI 792 (Spring 2020)
OPTI 792 (Fall 2019)
Research
BME 900 (Fall 2020)
Master's Report
BME 909 (Spring 2022)
Thesis
BME 910 (Spring 2023)
BME 910 (Fall 2022)
BME 910 (Spring 2022)
BME 910 (Fall 2021)
BME 910 (Spring 2021)
OPTI 910 (Spring 2024)
OPTI 910 (Fall 2023)
OPTI 910 (Spring 2023)
Dissertation
BME 920 (Fall 2024)
BME 920 (Spring 2024)
BME 920 (Fall 2023)
BME 920 (Spring 2021)
BME 920 (Fall 2020)
BME 920 (Spring 2020)
BME 920 (Fall 2019)
BME 920 (Spring 2019)
BME 920 (Fall 2018)
OPTI 920 (Spring 2024)
OPTI 920 (Fall 2023)
OPTI 920 (Spring 2023)
OPTI 920 (Fall 2022)
OPTI 920 (Spring 2022)
OPTI 920 (Fall 2021)
OPTI 920 (Spring 2021)
OPTI 920 (Fall 2020)
Selected Publications
Chapters
- Si, J., Kipke, D. R., Witte, R. S., Lan, J., & Lin, S. (2002). Self-Organizing Maps. In Self-Organizing Maps. Springer, Boston, MA. doi:10.1007/978-1-4613-0259-9_5
Journals/Publications
- Alcaraz, P. E., Davidson, S. J., Shreeve, E., Meuschke, R., Romanowski, M., Witte, R. S., Porter, T. R., & Matsunaga, T. O. (2023). Thermal and Acoustic Stabilization Of Volatile Phase-Change Contrast Agents Via Layer-By-Layer Assembly. Ultrasound in medicine & biology, 49(5), 1058-1069.
- Kamali, A., Dieckhaus, L. A., Peters, E. C., Preszler, C. A., Witte, R. S., Pires, P. W., Hutchinson, E. B., & Laksari, K. (2023).
Ultrasound, photoacoustic, and magnetic resonance imaging to study hyperacute pathophysiology of traumatic and vascular brain injury
. Journal of Neuroimaging, 33(4), 534-546. doi:10.1111/jon.13115
- Kamali, A., Dieckhaus, L. A., Peters, E. C., Preszler, C. A., Witte, R. S., Pires, P. W., Hutchinson, E. B., & Laksari, K. (2023). Ultrasound, photoacoustic, and magnetic resonance imaging to study hyperacute pathophysiology of traumatic and vascular brain injury. Journal of Neuroimaging (Official Journal of the American Society of Neuroimaging), 33(4), 534-546.
- Preston, C., Alvarez, A. M., Allard, M., Barragan, A., & Witte, R. S. (2023).
Acoustoelectric Time-Reversal for Ultrasound Phase-Aberration Correction
. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 70(8), 854-864. doi:10.1109/tuffc.2023.3292595
- Salinas, C. M., Reichel, E., Gupta, A., & Witte, R. S. (2023).
Heavy water coupling gel for short-wave infrared photoacoustic imaging
. Journal of Biomedical Optics, 28(11). doi:10.1117/1.jbo.28.11.116001
- Salinas, C. M., Reichel, E., Gupta, A., & Witte, R. S. (2023). Heavy water coupling gel for short-wave infrared photoacoustic imaging. Journal of biomedical optics, 28(11), 116001.
- Witte, R. S., Allard, M., Trujillo, T., Alvarez, A., Preston, C., Kang, J., & O'Donnell, M. (2023). Transcranial acoustoelectric imaging: Towards noninvasive mapping of current densities in the human brain. The Journal of the Acoustical Society of America, 153(3_supplement), A154-A154. doi:10.1121/10.0018479
- Kang, J., Huang, C., Perkins, C., Alvarez, A., Kunyansky, L., Witte, R. S., & O'Donnell, M. (2022). Current Source Density Imaging Using Regularized Inversion of Acoustoelectric Signals. IEEE transactions on medical imaging, PP.
- Witte, R. S., Ghosh, D., Salinas, C. M., Pallod, S., Roberts, J., Makin, I. R., Yaron, J. R., & Rege, K. (2022). Temporal evaluation of efficacy and quality of tissue repair upon laser‐activated sealing. Bioengineering & Translational Medicine. doi:10.1002/btm2.10412
- Witte, R. S., Kunyansky, L., Alvarez, A., Kang, J., Huang, C., Perkins, C., & O'Donnell, M. (2022). Current Source Density Imaging Using Regularized Inversion of Acoustoelectric Signals. IEEE Transactions on Medical Imaging, 1-1. doi:10.1109/tmi.2022.3215748
- Laksari, K., Witte, R., & Thurgood, H. (2021). 4D Reconstruction and Identification of Carotid Artery Stenosis Utilizing a Novel Pulsatile Ultrasound Phantom. Current Protocols, 1(10). doi:10.1002/cpz1.264
- Juneman, E., Lancaster, J., Novak, S., Witte, R., Chinyere, I., Weigand, K., Moukabary, T., Chu, M., Hutchinson, M., Gregorio, C., & Goldman, S. (2017). Abstract 86: Mapping and Inducing Ventricular Tachycardia in Cardiomyopathic Animal Models. Circulation Research, 121(suppl_1). doi:10.1161/res.121.suppl_1.86
- Wang, X., Qin, T., Witte, R. S., & Xin, H. (2017). Microwave-Induced Thermoacoustic Communications. IEEE Transactions on Microwave Theory and Techniques, 65(9), 3369-78.
- Witte, R. S., Furdella, K. J., & Vande Geest, J. P. (2017). Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy. Journal of Biomedical Optics, 22(4), 041016. doi:10.1117/1.jbo.22.4.041016
- Chinyere, I., Weigand, K., Moukabary, T., Witte, R. S., Lancaster, J., Goldman, S., & Juneman, E. B. (2016). Model of Induced Ventricular Tachycardia and Cardiac Electrophysiological Mapping. Circulation Research, 119(Supl 1), A 71.
Proceedings Publications
- Witte, R. S., Reichel, E., Salinas, C. M., & Curiel-Lewandrowski, C. (2022). Transparent Gellan Gum as an Efficient Coupling Media For Photoacoustic Imaging Applications. In 2022 IEEE International Ultrasonics Symposium (IUS).
- Gao, L., Schmitz, H. A., Zuniga, A. A., Klewer, J. A., Szivek, J. A., Taljanovic, M. S., Latt, L. D., & Witte, R. S. (2016). Neuronavigation with Skull Segmentation and Acoustic Modeling for Guiding Transcranial Acoustoelectric Brain Imaging. In 2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS).
- Witte, R. S., Tamimi, E., Reichel, E., & Curiel-Lewandrowski, C. (2021). Real-Time Trimodal Ultrasound, Photoacoustic, and Thermoacoustic Imaging for Biomedical Applications. In IEEE IUS.
- Latt, L. D., Zuniga, A. A., Witte, R. S., Taljanovic, M. S., Szivek, J. A., Stevens, T. J., Schmitz, H., & Latt, L. D. (2017). A model for use in the prognosis of tendinopathy. In ANSS '17: Proceedings of the 50th Annual Simulation Symposium 6RFLHW\IRU0RGHOLQJ 6LPXODWLRQ,QWHUQDWLRQDO 6&6, 49.
- Furdella, K., Witte, R. S., & Vande Geest, J. (2015, Summer). Tracking Mass Transport of a Drug Surrogate in Porcine Coronary Tissue using Photoacoustic Imaging and Spectroscopy. In Biomechanics, Bioengineering and Biotransport Conference.
- Qin, Y., Ingram, P., Wang, X., Qin, T., Xin, H., & Witte, R. S. (2014, 2014). Non-contact thermoacoustic imaging based on laser and microwave vibrometry. In 2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 1033-1036.
- Wang, X., Bauer, D., Witte, R., Xin, H., & , . (2015, 2013). Impact of Microwave Pulses on Microwave-Induced Thermoacoustic Imaging Applications. In 2013 USNC-URSI RADIO SCIENCE MEETING (JOINT WITH AP-S SYMPOSIUM), 210-210.
- Wang, X., Liang, M., Witte, R. S., & Xin, H. (2015, Summer). Fabrication of a realistic breast phantom based on 3D printing technology for thermoacoustic imaging application in breast cancer detection. In USNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 314.
- Wang, X., Witte, R. S., Liang, M., & Xin, H. (2015, Summer). Modeling of non-contact thermoacoustic imaging. In Proceedings IEEE, USNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 17.
- Witte, R. S., Wang, X., Xin, H., & Qin, T. (2015, March). Compressive sensing based contrast-enhanced thermoacoustic imaging for breast cancer detection. In 2015 31st International Review of Progress in Applied Computational Electromagnetics (ACES), 1-2.
- Bauer, D. R., Wang, X., Vollin, J., Xin, H., Witte, R. S., & , . (2014, 2012). Thermoacoustic Imaging and Spectroscopy for Enhanced Breast Cancer Detection. In 2011 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2364-2367.
- Huang, S., Rubin, J. M., Jia, C., Olafsson, R., Witte, R. S., O'Donnell, M., & , . (2014, 2007). Error analysis of axial displacement estimation in elasticity imaging. In 2007 IEEE ULTRASONICS SYMPOSIUM PROCEEDINGS, VOLS 1-6, 1969-1972.
- Panchangam, A., Witte, R. S., Claflin, D. R., O'Donnell, M., Faulkner, J. A., Farkas, D., Nicolau, D., & Leif, R. (2014, 2006). A novel optical imaging system for investigating sarcomere dynamics in single skeletal muscle fibers - art. no. 608808. In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IV, 6088, 8808-8808.
- Qin, T., Wang, X., Meng, H., Qin, Y., Wan, G., Witte, R. S., Xin, H., & , . (2014, 2014). Performance Improvement for Thermoacoustic Imaging Using Compressive Sensing. In 2014 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI), 1919-1920.
- Qin, Y., Wang, Z., Ingram, P., Li, Q., Witte, R. S., & , . (2014, 2012). Optimizing frequency and pulse shape for ultrasound current source density imaging. In 2011 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2138-2141.
Poster Presentations
- Preston, C., Kasoff, W., & Witte, R. S. (2018, April). Non-invasively mapping deep brain stimulation currents in 4D using acoustoelectric imaging. Minnesota Neuromodulation Symposium. Minneapolis, MN.
- Ingram, P., Bera, T., Burton, A., Hill, D. F., Wilhite, C. A., Witte, R. S., & Cowen, S. L. (2017, November). Acoustoelectric brain imaging: preliminary results in anesthetized rats. UA COM Founder's Day Junior Investigator Poster Forum.
- Martinez, J. A., Chalasani, P., Witte, R. S., Kwoh, C. K., Hadden, A., & Taljanovic, M. (2016, April). Imaging Biomarkers of Aromatase-Inhibitor Induced Joint Pain. University of Arizona, Cancer Center Retreat. Banner University Medical Center, Tucson, AZ.
- Schmitz, H., Witte, R. S., Gao, L., Latt, D. L., Ingram, C. P., Taljanovic, M., Klewer, J., Szivek, J. A., Klewer, J., Szivek, J. A., Ingram, C. P., Taljanovic, M., Gao, L., Latt, D. L., Schmitz, H., & Witte, R. S. (2016, January). Ultrasound Elasticity Imaging of the Posterior Tibial Tendon using FOCUS Simulation Software. 27th Annual Undergraduate Biology Research Program Conference. Tucson, AZ.
- Witte, R. S., Qin, Y., Ingram, P., Burton, A., Tseng, H., Hill, D. F., Wilhite, C. A., Falk, T., Xu, Z., O'Donell, M., & Cowen, S. L. (2016, Fall). Acoustoelectric Brain Imaging of Deep Dipole Sources in a Human Head Phantom. 3rd Annual BRAIN Initiative® Investigators Meeting.
Presentations
- Witte, R. S., Pires, P., & Hutchinson, E. B. (2021, Feb.). Mouse Brain Photoacoustic Imaging to Detect Hyper-Acute Pathophysiology Following Traumatic Brain Injury, Ischemia and Hemorrhage.. VisualSonics Live Imaging Workshop: “From Brain to Belly”VisualSonics.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Lorentz force impedance tomography in 2D: Theory and Experiments. Quantitative Biology Colloquium. U of A.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Rotational Magneto-Acousto-Electric Tomography: Theory and Experiments.. 100 years of the Radon transform. Johannes Keppler University, Linz, Austria.
- Witte, R. S., Ingram, P. C., & Kunyansky, L. (2017, Spring). Rotational Magneto-Acousto-Electric Tomography: Theory and Experiments.. Inverse Problems Seminar. University College London..
- Witte, R. S., Ingram, P., & Kunyansky, L. (2017, January). Lorentz force impedance tomography in 2D: Theory and Experiments. Inverse Problems Seminar.. Texas A&M University.
- Latt, D. L., Gao, L., Taljanovic, M., Szivek, J. A., Guerra, J. D., Klewer, J. A., & Witte, R. S. (2016, March). In Vivo Ultrasound Elasticity Imaging Differentiates Healthy From Diseased Tendons. Orthopaedic Research Society 2016 Annual Meeting. Orlando, Florida.
- Latt, D. L., Witte, R. S., Klewer, J. A., Gao, L., Guerra, J. D., Taljanovic, M., Szivek, J. A., Szivek, J. A., Guerra, J. D., Taljanovic, M., Gao, L., Klewer, J. A., Witte, R. S., Latt, D. L., Witte, R. S., Klewer, J. A., Guerra, J. D., Szivek, J. A., Taljanovic, M., , Gao, L., et al. (2016, March). In Vivo Ultrasound Elasticity Imaging Differentiates Healthy From Diseased Tendons. ORS 2016 Annual Meeting. Orlando, Florida.
- Taljanovic, M., Latt, D. L., Gao, L., & Witte, R. S. (2016, March). In Vivo Ultrasound Tension Elastography Differentiates Healthy From Diseased Posterior Tibialis tendon. 39th Annual Meeting of the Society of Skeletal Radiology (SSR). New Orleans, LA: Society of Skeletal Radiology.
Others
- Martinez, J. A., Chalasani, P., Witte, R. S., Kwoh, C. K., Hadden, A., Taljanovic, M., Martinez, J. A., Chalasani, P., Witte, R. S., Kwoh, C. K., Hadden, A., & Taljanovic, M. (2016, April). Imaging Biomarkers of Aromatase-Inhibitor Induced Joint Pain. University of Arizona, Cancer Center Retreat.
- Juneman, E., Lancaster, J., Witte, R., Bahl, J., & Goldman, S. (2012, AUG). Electrical Coupling of a Biological Active Cardiomyocyte Patch. JOURNAL OF CARDIAC FAILURE.
Awards
- Best Prototyping Award
- Mentored Senior Capstone Design Team (2017 - 2018), Fall 2017